Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity. (Q40051802)

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scientific article published on 14 November 2007

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English	Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.	scientific article published on 14 November 2007

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scholarly article

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26 December 2019

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity (English)

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26 December 2019

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26 December 2019

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Guy A Rutter

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26 December 2019

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Audrey Riboulet-Chavey

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26 December 2019

Frédérique Diraison

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26 December 2019

L Khai Siew

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14 November 2007

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26 December 2019

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9

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26 December 2019

57

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26 December 2019

415-423

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26 December 2019

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26 December 2019

The regulation of AMP-activated protein kinase by phosphorylation

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https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

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Apoptosis in the pathophysiology of diabetes mellitus

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https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

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https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

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Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase

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https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

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CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

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https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

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Regulation of caspase-6 and FLIP by the AMPK family member ARK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

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Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

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https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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NOD mice and autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Pancreatic islets under attack: cellular and molecular effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Early assessment of apoptosis in isolated islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic signal transduction pathways in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global and societal implications of the diabetes epidemic

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical islet transplantation: advances and immunological challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrating cytosolic calcium signals into mitochondrial metabolic responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The AMP-activated protein kinase pathway--new players upstream and downstream.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of Fas to diabetes development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

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The AMP-activated protein kinase cascade--a unifying system for energy control

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose potentiates cytokine- and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18003756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB07-0993

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26 December 2019

1 reference

Europe PubMed Central

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26 December 2019

1 reference

Europe PubMed Central

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26 December 2019

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