Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis (Q40056973)

16 September 2017

Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis (English)

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16 September 2017

Jenny Wong

1

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16 September 2017

Carmel M Quinn

series ordinal

2

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16 September 2017

Ingrid C Gelissen

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3

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16 September 2017

Andrew J Brown

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4

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16 September 2017

language of work or name

English

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publication date

2 November 2007

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Journal of Biological Chemistry

16 September 2017

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16 September 2017

283

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16 September 2017

2

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16 September 2017

700-707

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Biological activity of some oxygenated sterols

16 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

24(S),25-epoxycholesterol--a potential friend.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Liver X receptors as integrators of metabolic and inflammatory signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Transcriptional regulatory networks in lipid metabolism control ABCA1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

ABCA1 and atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

The Biological Synthesis of Cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

Protein sensors for membrane sterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706416200

21 January 2018

Identifiers

DOI

10.1074/JBC.M706416200

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16 September 2017

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