Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction (Q40068981)

7 June 2018

title

Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction (English)

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7 June 2018

11

Zhengyin Yan

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7 June 2018

author name string

Julia Ma

1

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7 June 2018

Shuo Wu

2

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7 June 2018

Xuexiang Zhang

3

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7 June 2018

Fang Guo

4

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7 June 2018

Katherine Yang

5

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7 June 2018

Jia Guo

6

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7 June 2018

Qing Su

7

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7 June 2018

Huagang Lu

8

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7 June 2018

Patrick Lam

9

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7 June 2018

Yuhuan Li

10

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7 June 2018

William Kinney

12

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7 June 2018

Ju-Tao Guo

13

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7 June 2018

Timothy M Block

14

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7 June 2018

Jinhong Chang

15

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7 June 2018

Yanming Du

16

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7 June 2018

publication date

17 January 2017

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7 June 2018

ACS Medicinal Chemistry Letters

published in

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7 June 2018

volume

8

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7 June 2018

issue

2

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7 June 2018

page(s)

157-162

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7 June 2018

Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents

cites work

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15 June 2018

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Multicolor imaging of endoplasmic reticulum-located esterase as a prodrug activation enzyme

15 June 2018

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Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions

15 June 2018

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Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses

15 June 2018

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Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection.

15 June 2018

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Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection

15 June 2018

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Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

15 June 2018

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Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus

15 June 2018

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Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Flaviviruses

15 June 2018

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Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs

15 June 2018

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Antiviral profiles of novel iminocyclitol compounds against bovine viral diarrhea virus, West Nile virus, dengue virus and hepatitis B virus

15 June 2018

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Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir

15 June 2018

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Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection

15 June 2018

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Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ.

15 June 2018

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Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071.

15 June 2018

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Purification and characterization of glucosidase I involved in N-linked glycoprotein processing in bovine mammary gland

15 June 2018

1 reference

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N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections

15 June 2018

1 reference

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Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus

17 June 2018

1 reference

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Effects of the imino sugar N-butyldeoxynojirimycin on the N-glycosylation of recombinant gp120.

20 August 2018

1 reference

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Species dependent esterase activities for hydrolysis of an anti-HIV prodrug glycovir and bioavailability of active SC-48334

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28197304

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACSMEDCHEMLETT.6B00332

1 reference

7 June 2018

PMCID

5304290

1 reference

7 June 2018

PubMed ID

28197304

1 reference

7 June 2018