Induction of heat shock proteins in differentiated human and rodent neurons by celastrol (Q40072158)

17 September 2017

Induction of heat shock proteins in differentiated human and rodent neurons by celastrol (English)

1 reference

17 September 2017

Ari M Chow

1

1 reference

PMCID

1971233

17 September 2017

Ian R Brown

series ordinal

2

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17 September 2017

1 January 2007

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17 September 2017

Cell Stress & Chaperones

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17 September 2017

12

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17 September 2017

3

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17 September 2017

237-244

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https://scigraph.springernature.com/pub.10.1379/csc-269.1

17 September 2017

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The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells

22 September 2017

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Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity

22 September 2017

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A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA.

22 September 2017

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Analysis of cag-8: a novel poly(Q)-encoding gene in the mouse brain

22 September 2017

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Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer's disease key proteins

22 September 2017

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Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells.

22 September 2017

1 reference

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Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation

22 September 2017

1 reference

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Modulation of neurodegeneration by molecular chaperones

22 September 2017

1 reference

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Celastrols as inducers of the heat shock response and cytoprotection.

22 September 2017

1 reference

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Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

22 September 2017

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Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies.

22 September 2017

1 reference

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Protein aggregation and neurodegenerative disease

22 September 2017

1 reference

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Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment

22 September 2017

1 reference

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Protein misfolding in neurodegenerative diseases

22 September 2017

1 reference

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Folding proteins in fatal ways

22 September 2017

1 reference

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

22 September 2017

1 reference

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Molecular chaperones in the cytosol: from nascent chain to folded protein

22 September 2017

1 reference

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The structural basis of protein folding and its links with human disease

22 September 2017

1 reference

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The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

22 September 2017

1 reference

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Mechanisms of neurodegenerative disorders: Part 1: protein aggregates.

22 September 2017

1 reference

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A hitchhiker's guide to the human Hsp70 family

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Localization of constitutive and hyperthermia-inducible heat shock mRNAs (hsc70 and hsp70) in the rabbit cerebellum and brainstem by non-radioactive in situ hybridization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Some progress on the chemistry of natural bioactive terpenoids form Chinese medicinal plants

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Temporal and spatial distribution of heat shock mRNA and protein (hsp70) in the rabbit cerebellum in response to hyperthermia

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Cell number-dependent regulation of Hsp70B' expression: evidence of an extracellular regulator

25 September 2017

1 reference

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Interferon-gamma increases neuronal death in response to amyloid-beta1-42.

17 June 2018

1 reference

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High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1971233

Teaching old drugs new tricks. Meeting of the Neurodegeneration Drug Screening Consortium, 7-8 April 2002, Washington, DC, USA

20 August 2018

1 reference

12 December 2020

Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study

1 reference

12 December 2020

Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Reduced induction of HSP70 in PC12 cells during neuronal differentiation

1 reference

12 December 2020

Neuronal differentiation in PC12 cells is accompanied by diminished inducibility of Hsp70 and Hsp60 in response to heat and ethanol

1 reference

12 December 2020

[In vitro inhibition of celastrol on spermatozoa fertilization ability of guinea pig]

1 reference

12 December 2020

Novel cytokine release inhibitors. Part I: Triterpenes

1 reference

12 December 2020

Thermotolerance and nuclear protein aggregation: protection against initial damage or better recovery?

1 reference

12 December 2020

Neurologists strike gold in drug screen effort

1 reference

12 December 2020

Identifiers

DOI

10.1379/CSC-269.1

1 reference

PMCID

1971233

Dimensions Publication ID

17 September 2017

0 references

1 reference

17 September 2017

1 reference

PMCID

1971233