SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation (Q40082905)

17 September 2017

SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation (English)

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17 September 2017

protein ubiquitination

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5

G L Semenza

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17 September 2017

M Tan

1

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17 September 2017

Q Gu

2

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17 September 2017

H He

3

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17 September 2017

D Pamarthy

4

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Y Sun

6

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17 September 2017

language of work or name

English

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publication date

10 September 2007

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17 September 2017

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27

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10

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17 September 2017

1404-1411

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210780

17 September 2017

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cites work

SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes.

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Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein

21 January 2018

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SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents

21 January 2018

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

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SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation

21 January 2018

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Hypoxia--a key regulatory factor in tumour growth

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

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The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

21 January 2018

1 reference

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

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VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

21 January 2018

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

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Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage

21 January 2018

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

21 January 2018

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The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

21 January 2018

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p53 and its downstream proteins as molecular targets of cancer

21 January 2018

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SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions

21 January 2018

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Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein

21 January 2018

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Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia

21 January 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

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Attenuation of ischemia-induced mouse brain injury by SAG, a redox-inducible antioxidant protein

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1038/SJ.ONC.1210780

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Dimensions Publication ID

17 September 2017

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