Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90. (Q40087723)

17 September 2017

Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90. (English)

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17 September 2017

1

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17 September 2017

Meike Broemer

2

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17 September 2017

Seda Cöl Arslan

3

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17 September 2017

Albrecht Otto

4

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17 September 2017

Eva-Christina Mueller

5

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17 September 2017

Rudolf Dettmer

6

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17 September 2017

Claus Scheidereit

7

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17 September 2017

language of work or name

English

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publication date

29 August 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

44

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17 September 2017

32311-32319

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17 September 2017

Signaling to NF-kappaB

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NF-kappaB: linking inflammation and immunity to cancer development and progression

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Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression

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Integrating cell-signalling pathways with NF-kappaB and IKK function

21 January 2018

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

21 January 2018

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Signals from within: the DNA-damage-induced NF-kappaB response

21 January 2018

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IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

21 January 2018

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The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.

21 January 2018

1 reference

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Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation

21 January 2018

1 reference

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Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation

21 January 2018

1 reference

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Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit

21 January 2018

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

1 reference

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Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

1 reference

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TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

21 January 2018

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In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

21 January 2018

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ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

21 January 2018

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The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase

21 January 2018

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Hsp90: chaperoning signal transduction

21 January 2018

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Structure and in vivo function of Hsp90.

21 January 2018

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Heat-shock protein 90, a chaperone for folding and regulation

21 January 2018

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

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Cdc37 goes beyond Hsp90 and kinases

21 January 2018

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Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

21 January 2018

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

21 January 2018

1 reference

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Functional specificity of co-chaperone interactions with Hsp90 client proteins.

21 January 2018

1 reference

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The Hsp90 cochaperone p23 is essential for perinatal survival.

21 January 2018

1 reference

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Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

21 January 2018

1 reference

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Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

21 January 2018

1 reference

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Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

21 January 2018

1 reference

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KSHV vFLIP binds to IKK-gamma to activate IKK.

21 January 2018

1 reference

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Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90.

21 January 2018

1 reference

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Inhibitors of the HSP90 molecular chaperone: current status

21 January 2018

1 reference

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A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

21 January 2018

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

21 January 2018

1 reference

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Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

21 January 2018

1 reference

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IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway

21 January 2018

1 reference

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

1 reference

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

1 reference

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p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

1 reference

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Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding

21 January 2018

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A client-binding site of Cdc37.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705785200

Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases

21 January 2018

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The conformational plasticity of protein kinases

21 January 2018

1 reference

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Regulation of protein kinases; controlling activity through activation segment conformation

21 January 2018

1 reference

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Molecular chaperones and protein kinase quality control.

21 January 2018

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Hsp90 Recognizes a Common Surface on Client Kinases

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M705785200

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17 September 2017

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