B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding (Q40106302)

17 September 2017

B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding (English)

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17 September 2017

Andreas Fischer

1

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17 September 2017

Mirko Hekman

2

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17 September 2017

Jürgen Kuhlmann

3

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17 September 2017

Ignacio Rubio

4

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17 September 2017

Stefan Wiese

5

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17 September 2017

Ulf R Rapp

6

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17 September 2017

language of work or name

English

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publication date

16 July 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

26503-26516

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17 September 2017

36

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BuCy RAFs drive cells into MEK addiction

17 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Human RAS superfamily proteins and related GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Ras proteins: different signals from different locations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Bioorganic synthesis of lipid-modified proteins for the study of signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Does Rap1 deserve a bad Rap?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

A permissive function of phosphoinositide 3-kinase in Ras activation mediated by inhibition of GTPase-activating proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Regulation and role of Raf-1/B-Raf heterodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Conformational switch and role of phosphorylation in PAK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Regulation of Raf-1 by direct feedback phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Activity of Rap1 is regulated by bombesin, cell adhesion, and cell density in NIH3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607458200

21 January 2018

Identifiers

DOI

10.1074/JBC.M607458200

1 reference

17 September 2017

1 reference