LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization (Q40116602)

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English	LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

17 September 2017

LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

author name string

T W Poh

1

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

S Huang

2

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

J L Hirpara

3

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

S Pervaiz

4

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

publication date

22 June 2007

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Europe PubMed Central

PubMed publication ID

17 September 2017

Cell Death & Differentiation

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Europe PubMed Central

PubMed publication ID

17 September 2017

14

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Europe PubMed Central

PubMed publication ID

17 September 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

1813-1825

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402177

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The TRAIL to selective tumor death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Death receptor-induced cell killing

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Apoptosis induced by death receptors

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

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21 January 2018

Sensitivity of prostate cells to TRAIL-induced apoptosis increases with tumor progression: DR5 and caspase 8 are key players

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Cell surface Death Receptor signaling in normal and cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspase-8 gene silencing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.

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21 January 2018

Mutagenicity of the fractionated organic emissions from diesel, cigarette smoke condensate, coke oven, and roofing tar in the Ames assay.

1 reference

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21 January 2018

Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.

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21 January 2018

Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling

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21 January 2018

Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells

1 reference

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21 January 2018

Mechanisms of cytochrome c release from mitochondria

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21 January 2018

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Insulin regulates cleavage of procaspase-9 via binding of X chromosome-linked inhibitor of apoptosis protein in HT-29 cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Death receptor 4 (DR4) efficiently kills breast cancer cells irrespective of their sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage.

1 reference

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21 January 2018

A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice

1 reference

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21 January 2018

Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells

1 reference

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21 January 2018

Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).

1 reference

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21 January 2018

Persistent inhibition of FLIP(L) expression by lentiviral small hairpin RNA delivery restores death-receptor-induced apoptosis in neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402177

21 January 2018

Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells.

1 reference

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21 January 2018

The complexity of TNF-related apoptosis-inducing ligand

1 reference

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Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells

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Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils

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The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism

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FADD expression and caspase activation in B-cell lymphomas resistant to Fas-mediated apoptosis

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Identifiers

10.1038/SJ.CDD.4402177

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Dimensions Publication ID

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

ResearchGate publication ID

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