Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins (Q40125495)

17 September 2017

Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins (English)

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17 September 2017

K G Wolter

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17 September 2017

M Verhaegen

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17 September 2017

Y Fernández

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17 September 2017

Z Nikolovska-Coleska

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17 September 2017

M Riblett

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17 September 2017

C Martin de la Vega

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17 September 2017

S Wang

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17 September 2017

M S Soengas

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17 September 2017

1 June 2007

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Cell Death & Differentiation

17 September 2017

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17 September 2017

14

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17 September 2017

1605-1616

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402163

17 September 2017

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Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma

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Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications.

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Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA.

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Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

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The development of proteasome inhibitors as anticancer drugs

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Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa

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The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

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Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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A phase II study of bortezomib in the treatment of metastatic malignant melanoma

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

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Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

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Targeting Bcl-2 and Bcl-X with nonpeptidic small-molecule antagonists

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

21 January 2018

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Investigations on gossypol: past and present developments

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Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

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A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

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Bcl-2 and bcl-xL antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

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Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2

21 January 2018

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21 January 2018

Cancer statistics, 2006

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7 January 2021

Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death

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7 January 2021

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

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7 January 2021

Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines

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7 January 2021

Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines.

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7 January 2021

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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7 January 2021

Cell biology. Cellular demolition and the rules of engagement

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7 January 2021

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402163

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Dimensions Publication ID

17 September 2017

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