Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK. (Q40126914)

17 September 2017

Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK. (English)

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17 September 2017

Zhen Y

1

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17 September 2017

Sørensen V

2

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17 September 2017

Jin Y

3

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17 September 2017

Suo Z

4

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17 September 2017

Wiedłocha A

5

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17 September 2017

language of work or name

English

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publication date

28 May 2007

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17 September 2017

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17 September 2017

26

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44

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17 September 2017

6372-6385

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210473

17 September 2017

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

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Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase

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Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

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Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

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Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction

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Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia

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8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways

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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

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Cell cycle-dependent nuclear localization of exogenously added fibroblast growth factor-1 in BALB/c 3T3 and human vascular endothelial cells.

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Evolution of the Fgf and Fgfr gene families

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From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors

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Multiple activation mechanisms of p38alpha mitogen-activated protein kinase

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Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase

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Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex

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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

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Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

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The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway.

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Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons

21 January 2018

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Activation of mitogen-activated protein kinases by tributyltin in CCRF-CEM cells: role of intracellular Ca(2+).

21 January 2018

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t(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210473

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1210473

1 reference

Dimensions Publication ID

17 September 2017

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1 reference