Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase. (Q40138658)

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30 December 2019

title

Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase (English)

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30 December 2019

1

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30 December 2019

Mark P Burns

2

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30 December 2019

author name string

Lilit Vardanian

3

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30 December 2019

Angelique Augustin

4

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30 December 2019

Helmut Jacobsen

5

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30 December 2019

Karlheinz Baumann

6

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30 December 2019

G William Rebeck

7

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30 December 2019

language of work or name

English

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publication date

1 May 2007

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Journal of Neurochemistry

30 December 2019

number of pages

8

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based on heuristic

inferred from page(s)

published in

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30 December 2019

volume

101

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30 December 2019

issue

4

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30 December 2019

page(s)

929-936

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Inflammation and Alzheimer's disease

30 December 2019

cites work

1 reference

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

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Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

21 January 2018

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Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.

21 January 2018

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The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

21 January 2018

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Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

21 January 2018

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

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The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

21 January 2018

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The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

21 January 2018

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

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ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease

21 January 2018

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

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Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

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