Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination (Q40140017)

17 September 2017

Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination (English)

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modulation by virus of host process

17 September 2017

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dengue virus protein NS1

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based on heuristic

inferred from abstract

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Dustin R Glasner

4

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Eva Harris

6

object named as

Eva Harris

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17 September 2017

P Robert Beatty

1

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17 September 2017

Henry Puerta-Guardo

2

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17 September 2017

Sarah S Killingbeck

3

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17 September 2017

Kaycie Hopkins

5

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17 September 2017

language of work or name

English

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publication date

1 September 2015

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Science Translational Medicine

17 September 2017

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17 September 2017

7

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17 September 2017

304ra141

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17 September 2017

304

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The global distribution and burden of dengue

17 September 2017

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

The burden of dengue infection.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Immunopathological mechanisms in dengue and dengue hemorrhagic fever

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Secreted NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate E

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Molecular mimicry between virus and host and its implications for dengue disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Synergistic Interactions of Anti-NS1 Monoclonal Antibodies Protect Passively Immunized Mice from Lethal Challenge with Dengue 2 Virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Non-structural proteins of dengue 2 virus offer limited protection to interferon-deficient mice after dengue 2 virus challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Protective immunity to DENV2 after immunization with a recombinant NS1 protein using a genetically detoxified heat-labile toxin as an adjuvant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

The dengue virus non-structural 1 protein: risks and benefits

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Evaluation of a DNA vaccine candidate expressing prM-E-NS1 antigens of dengue virus serotype 1 with or without granulocyte-macrophage colony-stimulating factor (GM-CSF) in immunogenicity and protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Preliminary evaluation of DNA vaccine candidates encoding dengue-2 prM/E and NS1: their immunity and protective efficacy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Characterization of a model of lethal dengue virus 2 infection in C57BL/6 mice deficient in the alpha/beta interferon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Phylogenetic evidence for adaptive evolution of dengue viruses in nature.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

The pathology of severe dengue in multiple organs of human fatal cases: histopathology, ultrastructure and virus replication

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Systemic vascular leakage associated with dengue infections - the clinical perspective

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Signaling mechanisms regulating endothelial permeability

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Antibodies against West Nile Virus Nonstructural Protein NS1 Prevent Lethal Infection through Fc Receptor-Dependent and -Independent Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Human Dengue antibodies against structural and nonstructural proteins

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: implications for viral infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Direct complement restriction of flavivirus infection requires glycan recognition by mannose-binding lectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

Murine Model for Dengue Virus-Induced Lethal Disease with Increased Vascular Permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA3787

10.1126/SCITRANSLMED.AAA3787

21 January 2018

Identifiers

DOI

1 reference

17 September 2017

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