A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease (Q40144785)

17 September 2017

title

A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease (English)

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17 September 2017

Da-Long Zhao

1

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17 September 2017

Li-Bo Zou

2

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17 September 2017

Lan-Fang Zhou

3

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17 September 2017

Ping Zhu

4

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17 September 2017

Hai-Bo Zhu

5

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17 September 2017

publication date

1 May 2007

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Acta Pharmacologica Sinica

17 September 2017

published in

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17 September 2017

volume

28

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17 September 2017

issue

5

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17 September 2017

page(s)

616-626

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https://scigraph.springernature.com/pub.10.1111/j.1745-7254.2007.00539.x

17 September 2017

exact match

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cites work

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

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Identification of two distinct synucleins from human brain

21 January 2018

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

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Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation

21 January 2018

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Slowness of movement in Parkinson's disease

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Staging of brain pathology related to sporadic Parkinson's disease

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MPTP: insights into parkinsonian neurodegeneration

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Experimental models of Parkinson's disease

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Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

21 January 2018

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Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells

21 January 2018

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Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases

21 January 2018

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Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

21 January 2018

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21 January 2018

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Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease?

21 January 2018

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Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

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alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

21 January 2018

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Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

21 January 2018

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Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

21 January 2018

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Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

21 January 2018

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

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Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human

21 January 2018

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Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death

21 January 2018

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Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide

21 January 2018

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Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the α-synuclein gene in early onset patients

21 January 2018

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10.1111/J.1745-7254.2007.00539.X

21 January 2018

Identifiers

DOI

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Dimensions Publication ID

17 September 2017

1007714680

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1 reference