BLK proto-oncogene, Src family tyrosine kinase (Q401536)

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mammalian protein found in Homo sapiens

• BLK
• p55-Blk
• b lymphocyte kinase
• B lymphoid tyrosine kinase
• BLK nonreceptor tyrosine kinase
• tyrosine-protein kinase Blk

edit

Language	Label	Description	Also known as
English	BLK proto-oncogene, Src family tyrosine kinase	mammalian protein found in Homo sapiens	BLK p55-Blk b lymphocyte kinase B lymphoid tyrosine kinase BLK nonreceptor tyrosine kinase tyrosine-protein kinase Blk

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P51451

part of

SH3-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

SH2 domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase Blk, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P51451

encoded by

BLK

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P51451

molecular function

transferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

nucleotide binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

protein kinase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

non-membrane spanning protein tyrosine kinase activity

determination method

IDA

IEA

2 references

retrieved

27 March 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51451&geneProductId=UniProtKB:P51451

determination method

IEA

retrieved

27 March 2018

stated in

Restoration of the function of bilateral hand grip at the expense of the fingers of the same hand

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51451&geneProductId=UniProtKB:P51451

determination method

IDA

kinase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

protein binding

determination method

IPI

4 references

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IPI

retrieved

8 April 2019

stated in

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IPI

retrieved

8 April 2019

stated in

A quantitative protein interaction network for the ErbB receptors using protein microarrays

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IPI

retrieved

8 April 2019

stated in

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IPI

protein tyrosine kinase activity

determination method

TAS

IEA

3 references

retrieved

10 September 2018

stated in

Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51451&geneProductId=UniProtKB:P51451

determination method

TAS

retrieved

10 September 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51451&geneProductId=UniProtKB:P51451

determination method

IEA

retrieved

10 September 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51451&geneProductId=UniProtKB:P51451

determination method

IEA

signaling receptor binding

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IBA

ATP binding

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

non-membrane spanning protein tyrosine kinase activity

determination method

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

retrieved

8 April 2019

stated in

Restoration of the function of bilateral hand grip at the expense of the fingers of the same hand

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IBA

protein tyrosine kinase activity

determination method

IDA

IEA

TAS

4 references

retrieved

8 April 2019

stated in

Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

retrieved

8 April 2019

stated in

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IDA

cell component

membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

extrinsic component of cytoplasmic side of plasma membrane

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IBA

plasma membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

cytosol

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

TAS

biological process

B cell receptor signaling pathway

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Restoration of the function of bilateral hand grip at the expense of the fingers of the same hand

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IDA

cell differentiation

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IBA

intracellular signal transduction

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

TAS

phosphorylation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IBA

protein phosphorylation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IEA

regulation of cell population proliferation

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51451&geneProductId=UniProtKB:P51451

determination method

IBA

peptidyl-tyrosine autophosphorylation

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IBA

innate immune response

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51451&geneProductId=UniProtKB:P51451

determination method

IBA

positive regulation of insulin secretion

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IMP

cell migration

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51451&geneProductId=UniProtKB:P51451

determination method

IBA

regulation of B cell receptor signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

TAS

peptidyl-tyrosine phosphorylation

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

GOA

curator

UniProt

UniProt protein ID

P51451

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51451

determination method

IDA

physically interacts with

ibrutinib

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6912

language of work or name

English

retrieved

17 August 2016

Gene Atlas image

PBB GE BLK 206255 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P51451

1 reference

stated in

Identifiers.org

has part(s)

SH3 domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

protein kinase, ATP binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

protein kinase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

tyrosine-protein kinase, catalytic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

SH2 domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

Tyrosine-protein kinase Blk, SH2 domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51451

Identifiers

RefSeq protein ID

NP_001317394

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

640

NP_001706

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

640

XP_011542126

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

640

XP_011542127

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

640

XP_011542129

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

640

XP_011542130

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

640

XP_011542131

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

640

UniProt protein ID

P51451

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P51451

Ensembl protein ID

ENSP00000259089

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000259089

ENSP00000433663

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000433663

ENSP00000494690

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000494690

ENSP00000494522

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000494522

ENSP00000496520

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000496520

Freebase ID

/m/03gz0m8

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q401536&oldid=2022900914"