Pharmacokinetics and toxicity testing (Q40182378)

18 September 2017

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title

Pharmacokinetics and toxicity testing (English)

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18 September 2017

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Clark B

1

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18 September 2017

Smith DA

series ordinal

2

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18 September 2017

language of work or name

English

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publication date

1 January 1984

1 reference

Critical Reviews in Toxicology

18 September 2017

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18 September 2017

12

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18 September 2017

343-385

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18 September 2017

4

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Saturable metabolism and its relationship to toxicity

18 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Inhalation pharmacokinetics based on gas uptake studies. I. Improvement of kinetic models.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Absorption of the β-Adrenergic-Blocking Agent, Nadolol, by Mice, Rats, Hamsters, Rabbits, Dogs, Monkeys, and Man: An Unusual Species Difference

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Disposition and Metabolism of Atenolol in Animals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The metabolic fate of the coronary dilator 4-(3,4,5,-trimethoxycinnamoyl)-1-(N-isopropylcarbamoylmethyl)-piperazine in the rat, dog and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The metabolic fate of the coronary vasodilator 4-(3,4,5-Trimethoxycinnamoyl)-1-(N-pyrrolidinocarbonylmethyl)piperazine (cinepazide) in the rat, dog and man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The Metabolism of Tolamolol* in the Mouse, Rat, Guinea-pig, Rabbit and Dog

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The disposition and metabolism of I.C.I. 58,834 (viloxazine) in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The disposition of [14C]iprindole in man, dog, miniature swine, rhesus monkey and rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The Disposition and Metabolism of Flurbiprofen in Several Species Including Man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Metabolism of 2-Benzylthio-5-Trifluoromethyl Benzoic Acid (BTBA) by the Rat, Dog and Man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The metabolism of tamoxifen (I.C.I. 46,474). I. In laboratory animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The Physiological Disposition of the Anti-tussive Agent, 1, 2, 3, 4, 4a, 9b- Hexahydro-8, 9b-dimethyl-4- [3-(4-methylpiperazin-1-yl)propionamido]dibenzofuran-3-one Dihydrochloride Azipranone®, in Man, Rat, Dog and Baboon

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The metabolism of talampicillin in rat, dog and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Length and Absorptive Surface Area Apportionment of Segments of the Hindgut for Eight Species of Small Mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Complication in Using Rabbits for the Study of Oral Drug Absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Studies on metabolism of trazodone. IV. Intestinal absorption in rats and rabbits.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Enteric transport of chlordecone (Kepone®) in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

GI pharmacology of polyethyleneimine I: effects on gastric emptying in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Metabolic Disposition of 6-Ethyl-3-(1H-tetrazol-5-yl)-chromone, a New Antiallergic Agent, in the Rat, Guinea-pig, Rabbit, Dog and Monkey

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The influence of gastric emptying on plasma concentrations of the analgesic, meptazinol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Effect of an Anticholinergic Agent on Riboflavin Absorption in Man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Presystemic Drug Elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Regional hemodynamic effects of beta-adrenergic blockade with propranolol in the unanesthetized primate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Influence of phenobarbital on the disposition of clonazepam and antipyrine in the dog

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Pharmacokinetics and bioavailability of cimetidine in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Influence of congestive heart failure on blood levels of lidocaine and its active monodeethylated metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Hepatic clearance of local anesthetics in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Rectal bioavailability of lidocaine in rats: absence of significant first-pass elimination.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Pharmacokinetics and distribution properties of pentobarbital in humans following oral and intravenous administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Enterohepatic Recirculation of Drugs as a Determinant of Therapeutic Ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Drug kinetics in childbirth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Comparison of rate of Hepatic Metabolismin vitroand Half-Life for Antipyrinein vivoin Three Species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The mechanism of hepatotoxicity of a chromone carboxylic acid (FPL 52757) in the dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Biological effects of furosemide in relation to its disposition in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Lidocaine pharmacokinetics in pregnant and nonpregnant sheep.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Pharmacokinetic studies in man with gallamine triethiodide. I. Single and multiple clinical doses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Protein Binding and Kinetics of Drugs in Liver Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Effect of Sulfadimethoxine on Thiopental Distribution and Elimination in Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Pharmacokinetic Consequences of Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Species Differences in Microsomal Monooxygenase Activity and Their Relationship to Biological Half-Lives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Improved delivery through biological membranes VIII: Design, synthesis, and in vivo testing of true prodrugs of aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Changes in liver blood flow during enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Hepatic blood flow and enzyme induction in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Species differences in the disposition and metabolism of sulfinpyrazone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Biliary Excretion of Drugs and Other Xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Metabolism of Arylacetic Acids: 1. The Fate of 1-Naphthylacetic Acid and its Variation with Species and Dose

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The Influence of Dose on the Pattern of Conjugation of Phenol and 1-Naphthol in Non-Human Primates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Some pathways of xenobiotic metabolism in the adult and neonatal marmoset (Callithrix jacchus).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Mixed-function oxidase activity in a desert rodent, Notomys alexis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

The ferret, Mustela putorius furo, as a new species in toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Rates of choleresis in various species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Acute and subacute toxicity studies with fortimicin A sulfate (Abbott-44747), a new aminoglycoside antibiotic.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Pharmacokinetics in renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Drug pharmacokinetics in cardiac and hepatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Disposition and Metabolism of Benoxaprofen in Laboratory Animals and Man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Altered Hepatic Blood Flow and Drug Disposition1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Effect of age on levels of diazepam in plasma and brain of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

Polymorphic hydroxylation of Debrisoquine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448409044214

10.3109/10408448409044214

21 January 2018

Identifiers

DOI

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1 reference