Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex (Q40203762)

18 September 2017

Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex (English)

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18 September 2017

J W Keller

1

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18 September 2017

K M Haigis

2

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18 September 2017

J L Franklin

3

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18 September 2017

R H Whitehead

4

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18 September 2017

T Jacks

5

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18 September 2017

R J Coffey

6

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18 September 2017

language of work or name

English

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publication date

20 November 2006

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18 September 2017

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18 September 2017

26

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18 September 2017

21

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18 September 2017

3051-3059

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210103

18 September 2017

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cites work

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

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Histone acetylation and cancer

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Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes

21 January 2018

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

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Targeting RAS signalling pathways in cancer therapy

21 January 2018

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Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

21 January 2018

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Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

21 January 2018

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Constitutive association of c-N-Ras with c-Raf-1 and protein kinase C epsilon in latent signaling modules

21 January 2018

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Ras proteins: different signals from different locations

21 January 2018

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All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

21 January 2018

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Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression

21 January 2018

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Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis

21 January 2018

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Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

21 January 2018

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Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release

21 January 2018

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Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC

21 January 2018

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Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation

21 January 2018

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Inhibition of apoptosis by the actin-regulatory protein gelsolin

21 January 2018

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Direct visualization of Ras proteins in spatially distinct cell surface microdomains

21 January 2018

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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

21 January 2018

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Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling

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Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

21 January 2018

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The murine N-ras gene is not essential for growth and development

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Genetic alterations during colorectal-tumor development

21 January 2018

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Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

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The p21 ras C-terminus is required for transformation and membrane association

21 January 2018

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Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38

21 January 2018

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Stimulation of p21 ras upon T-cell activation

21 January 2018

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Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein

21 January 2018

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Ras signalling on the endoplasmic reticulum and the Golgi

21 January 2018

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7 January 2021

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

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7 January 2021

K-ras is essential for the development of the mouse embryo

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7 January 2021

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

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7 January 2021

A method for the isolation and culture of human colonic crypts in collagen gels

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7 January 2021

Endogenous c-N-Ras provides a steady-state anti-apoptotic signal

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210103

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Dimensions Publication ID

18 September 2017

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1 reference