Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy (Q40204332)

18 September 2017

Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy (English)

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18 September 2017

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18 September 2017

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author name string

Janet M Dubinsky

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2

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18 September 2017

C Dirk Keene

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3

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18 September 2017

Walter C Low

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5

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18 September 2017

language of work or name

English

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publication date

8 January 2007

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Journal of Neurochemistry

18 September 2017

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18 September 2017

100

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18 September 2017

5

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18 September 2017

1397-1406

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Mitochondria take center stage in aging and neurodegeneration

18 September 2017

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Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease

22 September 2017

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Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect

22 September 2017

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Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

22 September 2017

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Huntingtin and its role in neuronal degeneration

22 September 2017

1 reference

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Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T.

22 September 2017

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N-acetylaspartate: a literature review of animal research on brain ischaemia.

22 September 2017

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Onset and rate of striatal atrophy in preclinical Huntington disease

22 September 2017

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The role of taurine in the central nervous system and the modulation of intracellular calcium homeostasis

22 September 2017

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Taurine and neural cell damage

22 September 2017

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

22 September 2017

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Clinical correlation of striatal 1H MRS changes in Huntington's disease

22 September 2017

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Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid.

22 September 2017

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Proton MRS in neurological disorders

22 September 2017

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In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time

22 September 2017

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Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study

22 September 2017

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

22 September 2017

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

22 September 2017

1 reference

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Trinucleotide repeat length instability and age of onset in Huntington's disease

22 September 2017

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Automatic, localized in vivo adjustment of all first- and second-order shim coils

22 September 2017

1 reference

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Characterization of the major brain osmolytes that accumulate in salt-loaded rats

22 September 2017

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Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

22 September 2017

1 reference

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Evidence for a membrane defect in Alzheimer disease brain

22 September 2017

1 reference

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Fine structural localization of glutamine synthetase in astrocytes of rat brain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice

25 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Immunocytochemical localization of cysteine sulfinate decarboxylase in astrocytes in the cerebellum and hippocampus: a quantitative double immunofluorescence study with glial fibrillary acidic protein and S-100 protein

15 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Multinuclear NMR studies on the energy metabolism of glial and neuronal cells

15 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Neuropathological classification of Huntington's disease

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Cerebral cation shifts and amino acids in Huntington's disease

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gamma-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Decreased brain N-acetylaspartate in Huntington's disease

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Glycerophosphorylcholine phosphocholine phosphodiesterase activity in cultured oligodendrocytes, astrocytes, and central nervous tissue of dysmyelinating rodent mutants

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Insulin and brain metabolism. Absence of direct action of insulin on K+ and Na+ transport in normal rabbit brain

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

New magnetic resonance spectroscopy biomarker for monitoring neurodegenerative diseases: animal models

17 June 2018

1 reference

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Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Predictors of neuropathological severity in 100 patients with Huntington's disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Metabolic changes in quinolinic acid-lesioned rat striatum detected non-invasively by in vivo (1)H NMR spectroscopy

20 August 2018

1 reference

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Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.

20 August 2018

1 reference

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N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice

20 August 2018

1 reference

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Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy

20 August 2018

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Proton magnetic resonance spectroscopy of cerebrospinal fluid in neurodegenerative disease: indication of glial energy impairment in Huntington chorea, but not Parkinson disease

20 August 2018

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Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice.

20 August 2018

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Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain

20 August 2018

1 reference

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Huntington disease: clinical, genetic, and social aspects

20 August 2018

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1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers

20 August 2018

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Ascorbate-induced oxidative inactivation of Zn2+-glycerophosphocholine cholinephosphodiesterase

20 August 2018

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Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

20 August 2018

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Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory

20 August 2018

1 reference

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Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.

20 August 2018

1 reference

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CSF and serum metabolic profile of patients with Huntington's chorea: a study by high resolution proton NMR spectroscopy and HPLC.

20 August 2018

1 reference

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Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859960

Effect of chronic hypernatremic dehydration and rapid rehydration on brain carbohydrate, energy, and amino acid metabolism in weanling mice

20 August 2018

1 reference

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Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

20 August 2018

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Crossref

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04323.X

Field mapping without reference scan using asymmetric echo-planar techniques

21 January 2018

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12 December 2020

Estimation of metabolite concentrations from localized in vivo proton NMR spectra

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12 December 2020

Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo

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12 December 2020

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

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10.1111/J.1471-4159.2006.04323.X

Identifiers

DOI

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18 September 2017

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18 September 2017

PubMed publication ID

17217418

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