Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin (Q40235602)

18 September 2017

Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin (English)

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18 September 2017

Bai Y

1

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18 September 2017

Liu YJ

2

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18 September 2017

Wang H

3

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18 September 2017

Xu Y

4

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18 September 2017

Stamenkovic I

5

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18 September 2017

Yu Q

6

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18 September 2017

language of work or name

English

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publication date

4 September 2006

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18 September 2017

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18 September 2017

26

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18 September 2017

6

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18 September 2017

836-850

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209849

18 September 2017

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cites work

Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

CD44 is the principal cell surface receptor for hyaluronate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Genotype/phenotype correlations in type 2 neurofibromatosis (NF2): evidence for more severe disease associated with truncating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

The role of the CD44/ezrin complex in cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Screening for germ-line mutations in the NF2 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Mutations in the p53 gene occur in diverse human tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Matrix metalloproteinases in tumor invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Activation of the tumor suppressor merlin modulates its interaction with lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Angiopoietin-2 is implicated in the regulation of tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

Impaired interaction of naturally occurring mutant NF2 protein with actin-based cytoskeleton and membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

7 January 2021

New insights into the neurofibromatoses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

7 January 2021

Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

7 January 2021

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

7 January 2021

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

7 January 2021

The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

7 January 2021

Interdomain binding mediates tumor growth suppression by the NF2 gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209849

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209849

1 reference

Dimensions Publication ID

18 September 2017

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1 reference