JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport (Q40271687)

19 September 2017

title

JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport (English)

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19 September 2017

Gerardo Morfini

1

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19 September 2017

Gustavo Pigino

2

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19 September 2017

Györgyi Szebenyi

3

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19 September 2017

Yimei You

4

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19 September 2017

Sarah Pollema

5

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19 September 2017

Scott T Brady

6

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19 September 2017

language of work or name

English

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publication date

4 June 2006

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19 September 2017

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19 September 2017

volume

9

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19 September 2017

issue

7

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19 September 2017

page(s)

907-916

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Glutamine repeats and neurodegeneration

19 September 2017

cites work

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Polyglutamine expansion diseases: failing to deliver

21 January 2018

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Spinal and bulbar muscular atrophy: a trinucleotide-repeat expansion neurodegenerative disease

21 January 2018

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Biochemical and molecular characterization of diseases linked to motor proteins

21 January 2018

1 reference

Kinesin motors and disease

21 January 2018

1 reference

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

21 January 2018

1 reference

A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)

21 January 2018

1 reference

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

21 January 2018

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Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

21 January 2018

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Kinesin-mediated organelle translocation revealed by specific cellular manipulations

21 January 2018

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Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

21 January 2018

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Fast axonal transport misregulation and Alzheimer's disease

21 January 2018

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Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

21 January 2018

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Polyglutamine protein aggregation and toxicity are linked to the cellular stress response

21 January 2018

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Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death

21 January 2018

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A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm

21 January 2018

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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis

21 January 2018

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Neurofilament protein synthesis and phosphorylation

21 January 2018

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A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

21 January 2018

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A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

21 January 2018

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Identification of the critical features of a small peptide inhibitor of JNK activity

21 January 2018

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Protein aggregation and neurodegenerative disease

21 January 2018

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Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration

21 January 2018

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

21 January 2018

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

Clinical features and skewed X-chromosome inactivation in female carriers of X-linked recessive spinal and bulbar muscular atrophy

21 January 2018

1 reference

Regulation of androgen receptor levels: implications for prostate cancer progression and therapy

21 January 2018

1 reference

A mouse model of spinal and bulbar muscular atrophy

21 January 2018

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Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice.

21 January 2018

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Retardation in the slow axonal transport of cytoskeletal elements during maturation and aging

21 January 2018

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Role of JNK activation in apoptosis: a double-edged sword

21 January 2018

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Reduced axonal transport of the G4 molecular form of acetylcholinesterase in the rat sciatic nerve during aging

21 January 2018

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Diseases of unstable repeat expansion: mechanisms and common principles

21 January 2018

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Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization

21 January 2018

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Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death

21 January 2018

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In vitro translation of androgen receptor cRNA results in an activated androgen receptor protein

21 January 2018

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A and B forms of the androgen receptor are expressed in a variety of human tissues

21 January 2018

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7 January 2021

Regulation of kinesin: implications for neuronal development

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7 January 2021

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

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7 January 2021

Phosphorylation of neuronal kinesin heavy and light chains in vivo

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7 January 2021

c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.

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7 January 2021

Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

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7 January 2021

Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women

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7 January 2021

Binding of 7 alpha, 17 alpha-dimethyl-19-nortestosterone (mibolerone) to androgen and progesterone receptors in human and animal tissues

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7 January 2021

Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes

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7 January 2021

Identifiers

DOI

10.1038/NN1717

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Dimensions Publication ID

19 September 2017

1044780618

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