Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome". (Q40284486)

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scientific article published on 2 May 2006

Language	Label	Description	Also known as
English	Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome".	scientific article published on 2 May 2006

Statements

scholarly article

1 reference

Europe PubMed Central

19 September 2017

Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome". (English)

1 reference

Europe PubMed Central

19 September 2017

G protein-coupled receptor

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author name string

Farahdiba Jafri

1

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Europe PubMed Central

19 September 2017

Hesham M El-Shewy

2

1 reference

Europe PubMed Central

19 September 2017

Mi-Hye Lee

3

1 reference

Europe PubMed Central

19 September 2017

Margaret Kelly

4

1 reference

Europe PubMed Central

19 September 2017

Deirdre K Luttrell

5

1 reference

Europe PubMed Central

19 September 2017

Louis M Luttrell

6

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Europe PubMed Central

19 September 2017

language of work or name

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publication date

2 May 2006

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Europe PubMed Central

19 September 2017

number of pages

12

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

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19 September 2017

281

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28

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19346-19357

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Europe PubMed Central

19 September 2017

Regulation of G protein-coupled receptor signaling by scaffold proteins

1 reference

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G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction

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Arresting developments in heptahelical receptor signaling and regulation

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Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

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The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

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The EGF receptor as central transducer of heterologous signalling systems

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'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors

1 reference

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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

1 reference

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

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beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.

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Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

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Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

1 reference

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21 January 2018

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

1 reference

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21 January 2018

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

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EGFR signal transactivation in cancer cells

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Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

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Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.

1 reference

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A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis

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Homo- and hetero-oligomerization of beta-arrestins in living cells

1 reference

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Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins

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21 January 2018

Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis.

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Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor

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Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2

1 reference

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Protein kinase C alpha activates RAF-1 by direct phosphorylation

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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1 reference

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21 January 2018

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

1 reference

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21 January 2018

Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination

1 reference

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21 January 2018

Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination

1 reference

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21 January 2018

Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.

1 reference

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21 January 2018

Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription

1 reference

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21 January 2018

Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modes

1 reference

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21 January 2018

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

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21 January 2018

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

1 reference

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21 January 2018

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

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21 January 2018

Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap1-extracellular signal-regulated kinase pathway

1 reference

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21 January 2018

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

1 reference

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21 January 2018

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 reference

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Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

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21 January 2018

NK1 Receptor Fused to beta -Arrestin Displays a Single-Component, High-Affinity Molecular Phenotype

1 reference

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21 January 2018

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation

1 reference

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Visual arrestin activity may be regulated by self-association

1 reference

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Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

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Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

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21 January 2018

Identifiers

10.1074/JBC.M512643200

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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