Adenosine deaminase inhibitors: their role in chemotherapy and immunosuppression (Q40294354)

19 September 2017

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title

Adenosine deaminase inhibitors: their role in chemotherapy and immunosuppression (English)

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19 September 2017

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R I Glazer

1

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19 September 2017

publication date

1 January 1980

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Cancer Chemotherapy and Pharmacology

19 September 2017

published in

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19 September 2017

volume

4

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19 September 2017

issue

4

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19 September 2017

page(s)

227-235

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Structure of coformycin, an unusual nucleoside of microbial origin

19 September 2017

cites work

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12 December 2020

Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis

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12 December 2020

Effects of 2'-deoxycoformycin, 9-beta-D-arabinofuranosyladenine 5'-phosphate, and 1-beta-D-arabinofuranosylcytosine triple combination therapy on intracerebral leukemia 1210

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12 December 2020

Role of nonhistone chromosomal proteins in the regulation of histone gene expression

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12 December 2020

Biochemical basis of the increased activity of 9-beta-D-arabinofuranosyladenine in the presence of inhibitors of adenosine deaminase

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12 December 2020

Potentiation by 2'-deoxycoformycin of the inhibitory effect of xylosyladenine on nuclear RNA synthesis in L1210 cells in vitro

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12 December 2020

Effects of 2'-deoxycoformycin and erythro-9-(2-hydroxy-3-nornyl)adenine on plasma levels and urinary excretion of 9-beta-D-arabinofuranosyladenine in the mouse 1,2,3

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12 December 2020

Enhancement of the biological activity of adenosine analogs by the adenosine deaminase inhibitor 2'-deoxycoformycin

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12 December 2020

Treatment of acute lymphoblastic leukemia with 2'-deoxycoformycin: clinical and biochemical consequences of adenosine deaminase inhibition

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12 December 2020

Studies of the relationship between adenosine deaminase and immune function

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12 December 2020

Effect of an adenosine deaminase inhibitor on survival of mouse pancreatic islet allografts

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12 December 2020

Effect of erythro-9-(2-hydroxy-3-nonyl) adenine on purine and pyrimidine metabolism in the human peripheral lymphocyte during the early phases of phytohemagglutinin-mediated blastogenesis

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12 December 2020

Adenosine deaminase from human erythrocytes: Purification and effects of adenosine analogs

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12 December 2020

Influence of substituent ribose on transition state affinity in reactions catalyzed by adenosine deaminase

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12 December 2020

Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency

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12 December 2020

S -Adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin

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12 December 2020

Tight-binding inhibitors-II. Non-steady state nature of inhibition of milk xanthine oxidase by allopurinol and alloxanthine and of human erythrocytic adenosine deaminase by coformycin

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12 December 2020

Two approaches that increase the activity of analogs of adenine nucleosides in animal cells

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12 December 2020

Characterization of adenosine deaminase from normal colon and colon tumors. Evidence for tumor-specific variants

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12 December 2020

Adenylate deaminase: Potent inhibition by 2′-deoxycoformycin 5′-phosphate

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12 December 2020

Adenosine deaminase inhibition for immunosuppression

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12 December 2020

Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines

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12 December 2020

Evidence that the inhibitory effect of adenosine, but not cordycepin, on the methylation of nuclear RNA is mediated by S-adenosylhomocysteine hydrolase

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12 December 2020

Use of microbiologic and enzymatic assays in studies on the disposition of 2'-deoxycomformycin in the mouse

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12 December 2020

Adenosine metabolism in cultured lymphoid cells

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12 December 2020

Inhibition of brain adenosine deaminase by 2'-deoxycoformycin and erythro-9-(2-hydroxy-3-nonyl) adenine

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12 December 2020

Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease

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12 December 2020

Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo

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12 December 2020

Purine reutilization in phytohemagglutinin-stimulated human T-lymphocytes

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12 December 2020

Effect of an adenosine deaminase inhibitor on the uptake and metabolism of arabinosyl adenine (Vidarabine) by intact human erythrocytes

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12 December 2020

(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity

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12 December 2020

Antiproliferative effects of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and related compounds in combination with adenosine deaminase inhibitors against mouse leukemia L1210/C2 cells in culture

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12 December 2020

Inhibition of Newcastle disease virion messenger RNA (guanine-7-)-methyltransferase by analogues of S-adenosylhomocysteine

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12 December 2020

Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors

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12 December 2020

Mode of inhibition of coformycin on adenosine deaminase

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12 December 2020

Effect of 2′-deoxycoformycin on the biologic half-life of 9-β-d-arabinofuranosyladenine 5′-triphosphate in CHO cells

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12 December 2020

Enhancement of 9-beta-d-arabinofuranosyladenine cytotoxicity to mouse leukemia L1210 in vitro by 2'-deoxycoformycin

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12 December 2020

Enhancement of the antitumor activity of arabinofuranosyladenine of 2'-deoxycoformycin

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12 December 2020

The effect of nucleosides and deoxycoformycin on adenosine and deoxyadenosine inhibition of human lymphocyte activation

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12 December 2020

Studies on the effects of infusion of enzyme inhibitors on mouse adenosine deaminase

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12 December 2020

Tight binding inhibitors--VI. Interactions of deoxycoformycin and adenosine deaminase in intact human erythrocytes and sarcoma 180 cells

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12 December 2020

Toxicities of adenosine and 2'-deoxyadrenosine in L cells treated with inhibitors of adenosine deaminase

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12 December 2020

Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine

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12 December 2020

Tight-binding inhibitors--III. A new approach for the determination of competition between tight-binding inhibitors and substrates--inhibition of adenosine deaminase by coformycin.

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12 December 2020

Analysis by high-pressure liquid chromatography of 9-β-d-arabinofuranosyladenine 5′-triphosphate levels in murine leukemia cells

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12 December 2020

Characterization of the residual adenosine deaminating activity in the spleen of a patient with combined immunodeficiency disease and adenosine deaminase deficiency

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12 December 2020

Influence of Coformycin on the Cytostatic Activity of 9-β-D-Arabinofuranosyladenine and Adenosine in Mouse L5178y Cells

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12 December 2020

Deoxyadenosine antagonism of the antiviral activity of 9-beta-D-arabinofuranosyladenine and 9-beta-D-arabinofuranosylhypoxanthine

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12 December 2020

Inhibition of adenosine deaminase by co-vidarabine and its effect on the metabolic disposition of adenine arabinoside (vidarabine)

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12 December 2020

Evidence that xylosyladenine affects methylation by inhibition of S-adenosyl-L-methionine synthesis

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12 December 2020

Metabolism and disposition of erythro-9-(2-hydroxy-3-nonyl)[14C]adenine in the rhesus monkey

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12 December 2020

Adenosine Inhibition of Lymphocyte-Mediated Cytolysis: Possible Role of Cyclic Adenosine Monophosphate

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12 December 2020

Deoxyadenosine metabolism and toxicity in cultured L5178Y cells

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12 December 2020

Adenosine deaminase inhibitors: Differential effects on multiple forms of adenosine deaminase

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12 December 2020

Enhancement of the biological activity of cordycepin (3'-deoxyadenosine) by the adenosine deaminase inhibitor 2'-deoxycoformycin

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12 December 2020

ENZYME INHIBITORS. V. THE SYNTHESES OF 6-SUBSTITUTED-(9-HYDROXYALKYL)PURINES AND THEIR EVALUATION AS INHIBITORS OF ADENOSINE DEAMINASE

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12 December 2020

Potent inhibition of muscle 5′-AMP deaminase by the nucleoside antibiotics coformycin and deoxycoformycin

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12 December 2020

Human adenosine deaminase binding protein. Assay, purification, and properties

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12 December 2020

Biosynthesis of S-N6-methyladenosylhomocysteine, an inhibitor of RNA methyltransferases

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12 December 2020

Specificity of adenosine deaminase toward adenosine and 2'-deoxyadenosine analogues

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12 December 2020

The effects of 2′-deoxycoformycin on the action of cordycepin on nuclear RNA synthesis in regenerating liver

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12 December 2020

Specificity of adenosine deaminase inhibitors

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12 December 2020

Cordycepin and xylosyladenine: Inhibitors of methylation of nuclear RNA

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12 December 2020

Comparison of the activity of 2'-deoxycoformycin and erythro-9-(2-hydroxy-3-nonyl)adenine in vivo

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12 December 2020

Effect of a novel adenosine deaminase inhibitor (co-vidarabine, co-V) upon the antiviral activity in vitro and in vivo of vidarabine (Vira-Atm) for DNA virus replication

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12 December 2020

Erythro-9-(2-hydroxy-3-nonyl)adenine as a specific inhibitor of herpes simplex virus replication in the presence and absence of adenosine analogues

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12 December 2020

Adenosine deaminase deficiency and immunodeficiencies

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12 December 2020

Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease

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12 December 2020

Antiviral Activity of an Adenosine Deaminase Inhibitor: Decreased Replication of Herpes Simplex Virus

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12 December 2020

Inhibition for Immunosuppression

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12 December 2020

A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism

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12 December 2020

Molecular form of adenosine deaminase in severe combined immunodeficiency

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12 December 2020

The metabolism of 2'-deoxycoformycin by L1210 cells invitro

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12 December 2020

Metabolic formation of nucleoside-modified analogues of S-adenosylmethionine

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12 December 2020

Therapeutic effects of 9-beta-D-arabinofuranosyladenine and 2'-deoxycoformycin combinations on intracerebral leukemia

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12 December 2020

Adenine and Adenosine Are Toxic to Human Lymphoblast Mutants Defective in Purine Salvage Enzymes

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12 December 2020

Enzyme inhibition titration assay for 2′-deoxycoformycin and its application to the study of the relationship between drug concentration and tissue adenosine deaminase in dogs and rats

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12 December 2020

Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cells

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12 December 2020

Determination of plaque inhibitory activity of adenine arabinoside (9-beta-D-arabinofuranosyladenine) for herpesviruses using an adenosine deaminase inhibitor

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12 December 2020

Inhibition of the phosphorylation of nonhistone chromosomal proteins by cordycepin and xylosyladenine in L1210 cells in vitro

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12 December 2020

Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication

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12 December 2020

Potentiation by homocysteine of adenosine-stimulated elevation of cellular adenosine 3′,5′-monophosphate

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12 December 2020

A kinetic study of the deamination of some adenosine analogues. Substrate specificity of adenosine deaminase

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12 December 2020

Effects of 2'-deoxycoformycin infusion on mouse adenosine deaminase

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12 December 2020

Inhibition of the phosphorylation of non-histone chromosomal proteins of rat liver by cordycepin and cordycepin triphosphate

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12 December 2020

In vivo toxicity to lymphoid tissue by 2'-deoxycoformycin

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12 December 2020

Potentiation by 2'-deoxycoformycin of the inhibitory effect by 3'-deoxyadenosine (cordycepin) on nuclear RNA synthesis in L1210 cells in vitro

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12 December 2020

Identifiers

DOI

10.1007/BF00255266

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Dimensions Publication ID

19 September 2017

1006282411

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