Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase (Q40302517)

19 September 2017

Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase (English)

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19 September 2017

Kosuke Aritake

1

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19 September 2017

Yuji Kado

2

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19 September 2017

Tsuyoshi Inoue

3

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19 September 2017

Masashi Miyano

4

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19 September 2017

Yoshihiro Urade

5

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19 September 2017

language of work or name

English

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publication date

17 March 2006

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Journal of Biological Chemistry

19 September 2017

10

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based on heuristic

inferred from page(s)

published in

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19 September 2017

281

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19 September 2017

22

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19 September 2017

15277-15286

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Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

19 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Prostaglandin D synthase: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M506431200

Hematopoietic prostaglandin D synthase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M506431200

COX-2 inhibitors--lessons in drug safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Mechanism of metal activation of human hematopoietic prostaglandin D synthase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M506431200

First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Characterization of the unfolding process of lipocalin-type prostaglandin D synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages

21 January 2018

1 reference

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Induction of cyclooxygenase-1 in a human megakaryoblastic cell line (CMK) differentiated by phorbol ester

21 January 2018

1 reference

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Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

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RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Prostaglandin D synthase in human megakaryoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Cloning and crystal structure of hematopoietic prostaglandin D synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Hydrogen bonds with pi-acceptors in proteins: frequencies and role in stabilizing local 3D structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Prostaglandins inhibit 5-lipoxygenase-activating protein expression and leukotriene B4 production from dendritic cells via an IL-10-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Raster3D Version 2.0. A program for photorealistic molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

Identification and isolation of a membrane protein necessary for leukotriene production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506431200

21 January 2018

Identifiers

DOI

10.1074/JBC.M506431200

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19 September 2017

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