TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. (Q40319463)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16464865%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase (English)

1 reference

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16 January 2020

author name string

Huira Chong-Kopera

1

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16 January 2020

Ken Inoki

2

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16 January 2020

Yong Li

3

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16 January 2020

Tianqing Zhu

4

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16 January 2020

Kun-Liang Guan

7

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16 January 2020

language of work or name

English

0 references

publication date

7 February 2006

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Journal of Biological Chemistry

16 January 2020

published in

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16 January 2020

volume

281

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16 January 2020

issue

13

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16 January 2020

page(s)

8313-8316

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Tuberous sclerosis: from tubers to mTOR.

16 January 2020

cites work

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Upstream and downstream of mTOR

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

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TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

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Rheb fills a GAP between TSC and TOR.

21 January 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex

21 January 2018

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A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70.

21 January 2018

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Tumour suppressors hamartin and tuberin: intracellular signalling

21 January 2018

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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

21 January 2018

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Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

21 January 2018

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

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Signaling by target of rapamycin proteins in cell growth control

21 January 2018

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Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

21 January 2018

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Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

21 January 2018

1 reference

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

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The Rheb family of GTP-binding proteins

21 January 2018

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 January 2018

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Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

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Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1·TSC2 Complex

21 January 2018

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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

21 January 2018

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Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

21 January 2018

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The HERC proteins: functional and evolutionary insights.

21 January 2018

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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.C500451200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16464865%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference