Long-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degeneration. (Q40321814)

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scientific article published on February 2006

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English	Long-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degeneration.	scientific article published on February 2006

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16 January 2020

Long-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degeneration (English)

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16 January 2020

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16 January 2020

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16 January 2020

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16 January 2020

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Robert Evers

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16 January 2020

Joost Verhaagen

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1 February 2006

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16 January 2020

Journal of Neuroscience

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16 January 2020

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16 January 2020

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16 January 2020

1516-1530

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16 January 2020

Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins and synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TrkA glycosylation regulates receptor localization and activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adeno-associated virus vectors: activity and applications in the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurotrophin hypothesis for synaptic plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins: roles in neuronal development and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local and target-derived actions of neurotrophins during peripheral nervous system development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced number of functional glutamatergic synapses in hippocampal neurons overexpressing full-length TrkB receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of alpha-synuclein in non-apoptotic, slowly degenerating facial motoneurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetically engineered mouse models of neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adeno-associated viral vectors as agents for gene delivery: application in disorders and trauma of the central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trk receptors: roles in neuronal signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axotomy abolishes NeuN expression in facial but not rubrospinal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NeuN, a neuronal specific nuclear protein in vertebrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal reinjury reveals the survival and re-expression of regeneration-associated genes in chronically axotomized adult mouse motoneurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced branching and length of dendrites detected in cervical spinal cord motoneurons of wobbler mouse, a model for inherited motoneuron disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphology of motoneurons in different subdivisions of the rat facial nucleus stained intracellularly with horseradish peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphology of motoneurons in a mixed motor pool of the cat facial nucleus that innervate orbicularis oculis and quadratus labii superioris, stained intracellularly with horseradish peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neurotrophin receptor expression during embryonic and postnatal development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influences of neurotrophins on mammalian motoneurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of neurotrophins in skeletal muscle: Quantitative comparison and significance for motoneuron survival and maintenance of function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axotomy-induced apoptotic cell death of neonatal rat facial motoneurons: time course analysis and relation to NADPH-diaphorase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of BDNF and trkB mRNA in rat facial motoneurons after axotomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and function of TrkB variants in developing sensory neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult mammalian sensory and motor neurons: roles of endogenous neurotrophins and rescue by exogenous neurotrophins after axotomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor spares choline acetyltransferase mRNA following axotomy of motor neurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical localization of TrkB in the central nervous system of the adult rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF prevents and reverses adult rat motor neuron degeneration and induces axonal outgrowth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor promotes axonal regeneration and long-term survival of adult rat spinal motoneurons in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated trkB receptors on nonneuronal cells inhibit BDNF-induced neurite outgrowth in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional evidence that BDNF is an anterograde neuronal trophic factor in the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective and rapid uptake of adeno-associated virus type 2 in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of spinal motoneuron degeneration following different types of peripheral nerve injury in neonatal and adult mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: correlation with trkB and trkC mRNA levels and isoforms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel tools for production and purification of recombinant adenoassociated virus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4543-05.2006

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16452675%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16452675%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16452675%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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