Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases (Q40343230)

19 September 2017

Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases (English)

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19 September 2017

Sridhar SC

1

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19 September 2017

Miranti CK

series ordinal

2

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19 September 2017

language of work or name

English

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publication date

1 April 2006

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19 September 2017

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19 September 2017

25

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19 September 2017

16

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19 September 2017

2367-2378

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209269

19 September 2017

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Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells

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Unique expression pattern of the alpha6beta4 integrin and laminin-5 in human prostate carcinoma

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7 January 2021

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KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2

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Newest findings on the oldest oncogene; how activated src does it

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FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

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Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion

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Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane Microdomain

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Differential regulation of cell motility and invasion by FAK

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Correlation of reduction in MRP-1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients

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7 January 2021

Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway

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7 January 2021

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

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Prostate cancer and the met hepatocyte growth factor receptor

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High expression of the Met receptor in prostate cancer metastasis to bone

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Signaling through the tetraspanin CD82 triggers its association with the cytoskeleton leading to sustained morphological changes and T cell activation.

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Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.

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KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer

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Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

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7 January 2021

KAI1 metastasis suppressor gene is frequently down-regulated in cervical carcinoma

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7 January 2021

Frequent Down-Regulation and Lack of Mutation of the KAI1 Metastasis Suppressor Gene in Epithelial Ovarian Carcinoma

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7 January 2021

Effects of KAI1/CD82 on biological behavior of human colorectal carcinoma cell line

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7 January 2021

Application of cell adhesion to study signaling networks

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7 January 2021

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7 January 2021

Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma

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Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines

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Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src.

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7 January 2021

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7 January 2021

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7 January 2021

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Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR.

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7 January 2021

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7 January 2021

Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491).

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7 January 2021

c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells

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7 January 2021

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor

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7 January 2021

Different phenotypes in human prostate cancer: alpha6 or alpha3 integrin in cell-extracellular adhesion sites

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7 January 2021

The metastasis suppressor gene C33/CD82/KAI1 induces apoptosis through reactive oxygen intermediates

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7 January 2021

RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

FAK integrates growth-factor and integrin signals to promote cell migration

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Aneusomy of chromosomes 7, 8, and 17 and amplification of HER-2/neu and epidermal growth factor receptor in Gleason score 7 prostate carcinoma: a differential fluorescent in situ hybridization study of Gleason pattern 3 and 4 using tissue microarray

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors

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7 January 2021

Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene

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7 January 2021

PTEN gene and integrin signaling in cancer

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7 January 2021

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Intermediate cells in normal and malignant prostate epithelium express c-MET: implications for prostate cancer invasion

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Clustering of MHC-peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Frequent downregulation of the KAI1(CD82) metastasis suppressor protein in human cancer cell lines.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Tetraspanin proteins as organisers of membrane microdomains and signalling complexes.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Requirement of the p130CAS-Crk Coupling for Metastasis Suppressor KAI1/CD82-mediated Inhibition of Cell Migration

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209269

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209269

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Dimensions Publication ID

19 September 2017

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