Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. (Q40348831)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14679178%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

title

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction (English)

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22 December 2019

3

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22 December 2019

Louise T Dalgaard

4

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22 December 2019

author name string

Stefan Krauss

1

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22 December 2019

Chen-Yu Zhang

2

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22 December 2019

Julie St-Pierre

5

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22 December 2019

Shane T Grey

6

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22 December 2019

Bradford B Lowell

7

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22 December 2019

language of work or name

English

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publication date

1 December 2003

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Journal of Clinical Investigation

22 December 2019

published in

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22 December 2019

volume

112

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22 December 2019

page(s)

1831-1842

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22 December 2019

issue

12

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Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids

22 December 2019

cites work

1 reference

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Visualizing superoxide production in normal and diabetic rat islets of Langerhans

22 September 2017

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Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells

22 September 2017

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Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

22 September 2017

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A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

22 September 2017

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22 September 2017

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22 September 2017

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Superoxide activates mitochondrial uncoupling proteins

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

22 September 2017

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Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

22 September 2017

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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

22 September 2017

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Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

22 September 2017

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The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase

22 September 2017

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

22 September 2017

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Energy metabolism in uncoupling protein 3 gene knockout mice

22 September 2017

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22 September 2017

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22 September 2017

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Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release. Unmasking by decreasing a stable pool of adenine nucleotides in mouse islets

22 September 2017

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Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

22 September 2017

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Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

25 September 2017

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25 September 2017

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No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

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12 December 2020

Overexpression of catalase provides partial protection to transgenic mouse beta cells

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12 December 2020

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Interference of H2O2 with stimulus-secretion coupling in mouse pancreatic beta-cells

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12 December 2020

Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

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12 December 2020

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

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12 December 2020

Identifiers

DOI

10.1172/JCI200319774

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14679178%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14679178%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference