C-C motif chemokine receptor 2 (Q4035572)

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mammalian protein found in Homo sapiens

C-C chemokine receptor type 2
MCP-1-R
monocyte chemotactic protein 1 receptor
monocyte chemoattractant protein 1 receptor
MCP-1 receptor
chemokine (C-C motif) receptor 2
CD192
CCR2
Receptors, CCR2

Language	Label	Description	Also known as
English	C-C motif chemokine receptor 2	mammalian protein found in Homo sapiens	C-C chemokine receptor type 2 MCP-1-R monocyte chemotactic protein 1 receptor monocyte chemoattractant protein 1 receptor MCP-1 receptor chemokine (C-C motif) receptor 2 CD192 CCR2 Receptors, CCR2

Statements

1 reference

13 November 2019

UniProt protein ID

CC chemokine receptor 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41597

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein CCR2 PDB 1KAD.png
640 × 480; 102 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

CCR2 chemokine receptor binding

determination method or standard

1 reference

8 April 2019

Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

signal transducer activity

determination method or standard

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

Structural basis for the interaction of human β-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

cytokine binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

chemokine (C-C motif) ligand 2 binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

chemokine (C-C motif) ligand 12 binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

chemokine (C-C motif) ligand 7 binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

C-C chemokine receptor activity

determination method or standard

3 references

chemokine binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

C-C chemokine binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

integral component of membrane

determination method or standard

3 references

8 April 2019

Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

plasma membrane

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

8 April 2019

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

neuronal cell body

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

perinuclear region of cytoplasm

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

determination method or standard

1 reference

27 March 2018

Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

biological process

negative regulation of adenylate cyclase activity

determination method or standard

1 reference

8 April 2019

Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

receptor signaling pathway via JAK-STAT

determination method or standard

1 reference

8 April 2019

The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

chemokine-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

cellular calcium ion homeostasis

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

positive regulation of monocyte chemotaxis

determination method or standard

4 references

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

dendritic cell chemotaxis

determination method or standard

1 reference

8 April 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

response to wounding

determination method or standard

1 reference

8 April 2019

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

immune response

determination method or standard

3 references

27 March 2018

Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

inflammatory response

determination method or standard

3 references

27 March 2018

Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

positive regulation of astrocyte chemotaxis

determination method or standard

1 reference

8 April 2019

Functional expression of CCR2 by human fetal astrocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

positive regulation of cytosolic calcium ion concentration

determination method or standard

1 reference

27 March 2018

Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

monocyte chemotaxis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

humoral immune response

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

sensory perception of pain

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

determination method or standard

regulation of cell migration

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

homeostasis of number of cells within a tissue

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

leukocyte adhesion to vascular endothelial cell

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

neutrophil clearance

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

positive regulation of leukocyte tethering or rolling

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

determination method or standard

3 references

8 April 2019

Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

inflammatory response

determination method or standard

5 references

8 April 2019

Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

immune response

determination method or standard

4 references

8 April 2019

Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

positive regulation of cytosolic calcium ion concentration

determination method or standard

calcium-mediated signaling

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

cell chemotaxis

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

positive regulation of NMDA glutamate receptor activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

determination method or standard

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41597

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000292301

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000292301

ENSP00000383681

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000383681

ENSP00000399285

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399285

ENSP00000396736

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396736

0 references

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

2 references

12 October 2015

http://www.uniprot.org/uniprot/P41597.txt?162

14 November 2015

http://www.uniprot.org/uniprot/P41597.txt?version=164

2 references

12 October 2015

http://www.uniprot.org/uniprot/P41597.txt?162

14 November 2015

http://www.uniprot.org/uniprot/P41597.txt?version=164

Sitelinks

Wikipedia(7 entries)

dewiki CCR2
enwiki CCR2
frwiki CCR2
ruwiki CCR2
ttwiki CCR2
ukwiki CCR2
viwiki CCR2

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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