CD46 molecule (Q4035579)

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mammalian protein found in Homo sapiens

measles virus receptor
CD46
CD46 molecule, complement regulatory protein
membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
CD46 antigen, complement regulatory protein
TLX
trophoblast leukocyte common antigen
complement membrane cofactor protein
membrane cofactor protein
trophoblast-lymphocyte cross-reactive antigen
antigen identified by monoclonal antibody TRA-2-10
trophoblast leucocyte common antigen

Language	Label	Description	Also known as
English	CD46 molecule	mammalian protein found in Homo sapiens	measles virus receptor CD46 CD46 molecule, complement regulatory protein membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) CD46 antigen, complement regulatory protein TLX trophoblast leukocyte common antigen complement membrane cofactor protein membrane cofactor protein trophoblast-lymphocyte cross-reactive antigen antigen identified by monoclonal antibody TRA-2-10 trophoblast leucocyte common antigen

Statements

1 reference

13 November 2019

UniProt protein ID

membrane cofactor protein CD46

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15529

Sushi/SCR/CCP superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15529

Sushi/SCR/CCP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

virus receptor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

cadherin binding

determination method

1 reference

8 April 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

protein binding

determination method

1 reference

8 April 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

complement binding

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

endopeptidase activity

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

enzyme inhibitor activity

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

signaling receptor activity

determination method

1 reference

8 April 2019

The human CD46 molecule is a receptor for measles virus (Edmonston strain)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

inner acrosomal membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

determination method

1 reference

26 September 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

plasma membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

8 April 2019

Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

8 April 2019

Characterization of the membrane-targeting C1 domain in Pasteurella multocida toxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

extracellular exosome

determination method

1 reference

26 September 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

acrosomal vesicle

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

Golgi apparatus

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

basolateral plasma membrane

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

biological process

T cell mediated immunity

determination method

1 reference

8 April 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

adaptive immune response

determination method

1 reference

8 April 2019

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

positive regulation of interleukin-10 production

determination method

1 reference

8 April 2019

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

sequestering of extracellular ligand from receptor

determination method

1 reference

8 April 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

positive regulation of regulatory T cell differentiation

determination method

1 reference

8 April 2019

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

single fertilization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

positive regulation of T cell proliferation

determination method

1 reference

8 April 2019

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

positive regulation of memory T cell differentiation

determination method

1 reference

8 April 2019

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

complement activation, classical pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

positive regulation of transforming growth factor beta production

determination method

1 reference

8 April 2019

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

viral entry into host cell

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

regulation of Notch signaling pathway

determination method

1 reference

8 April 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

regulation of complement activation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

interleukin-10 production

determination method

1 reference

8 April 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

innate immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15529

determination method

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

negative regulation of catalytic activity

determination method

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

negative regulation of complement activation

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15529&geneProductId=UniProtKB:P15529

determination method

Gene Atlas image

PBB GE CD46 208783 s at fs.png
732 × 530; 11 KB

0 references

sushi/SCR/CCP domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15529

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000418471

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418471

ENSP00000313875

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000313875

ENSP00000314664

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000314664

ENSP00000346912

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000346912

ENSP00000350346

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000350346

ENSP00000350893

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000350893

ENSP00000353342

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353342

ENSP00000356008

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356008

ENSP00000356009

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356009

ENSP00000356014

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356014

ENSP00000473449

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473449

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(8 entries)

cywiki CD46
dewiki Membrancofaktorprotein
enwiki CD46
etwiki Membranoosse kofaktori proteiin
jawiki CD46
ruwiki CD46
ttwiki CD46
ukwiki CD46

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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