Dietary cholesterol promotes repair of demyelinated lesions in the adult brain (Q40360370)

19 September 2017

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain (English)

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19 September 2017

13

Wiebke Möbius

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author name string

Stefan A Berghoff

1

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19 September 2017

Nina Gerndt

2

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19 September 2017

Jan Winchenbach

3

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19 September 2017

Sina K Stumpf

4

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19 September 2017

Leon Hosang

5

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19 September 2017

Francesca Odoardi

6

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19 September 2017

Torben Ruhwedel

7

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19 September 2017

Carolin Böhler

8

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19 September 2017

Benoit Barrette

9

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19 September 2017

Ruth Stassart

10

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19 September 2017

David Liebetanz

11

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19 September 2017

Payam Dibaj

12

1 reference

19 September 2017

Wiebke Möbius

13

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19 September 2017

Julia M Edgar

14

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19 September 2017

Gesine Saher

15

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19 September 2017

language of work or name

English

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publication date

24 January 2017

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19 September 2017

Nature Communications

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19 September 2017

8

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19 September 2017

14241

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Creative Commons Attribution 4.0 International

19 September 2017

start time

24 January 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5286209/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms14241

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cites work

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Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling

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Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression.

22 September 2017

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Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination

22 September 2017

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IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination

22 September 2017

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Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation

22 September 2017

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FGF-2 and Anosmin-1 are selectively expressed in different types of multiple sclerosis lesions.

22 September 2017

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Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication

22 September 2017

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Fibroblast growth factor 1 (FGFR1) modulation regulates repair capacity of oligodendrocyte progenitor cells following chronic demyelination

22 September 2017

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Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming

22 September 2017

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Retinoid X receptor gamma signaling accelerates CNS remyelination

22 September 2017

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Structure and function of the blood-brain barrier

22 September 2017

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Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

22 September 2017

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Statin therapy inhibits remyelination in the central nervous system.

22 September 2017

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Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging

22 September 2017

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22 September 2017

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22 September 2017

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Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.

22 September 2017

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Remyelination protects axons from demyelination-associated axon degeneration

22 September 2017

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Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

22 September 2017

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Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions

22 September 2017

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

22 September 2017

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The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system.

22 September 2017

1 reference

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The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: a serial diffusion MRI study

22 September 2017

1 reference

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Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9.

22 September 2017

1 reference

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The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling.

25 September 2017

1 reference

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Central Nervous System Demyelination and Remyelination is Independent from Systemic Cholesterol Level in Theiler's Murine Encephalomyelitis

25 September 2017

1 reference

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A role for Apolipoprotein A-I in the pathogenesis of multiple sclerosis.

25 September 2017

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PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Blood cholesterol and MRI activity in first clinical episode suggestive of multiple sclerosis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone-intoxicated mice

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Pivotal role of choline metabolites in remyelination.

17 June 2018

1 reference

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Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Critical time window of neuronal cholesterol synthesis during neurite outgrowth.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Identification of a microglia phenotype supportive of remyelination

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Obesity predisposes to Th17 bias

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Active induction of experimental allergic encephalomyelitis.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Distinct fibroblast growth factor (FGF)/FGF receptor signaling pairs initiate diverse cellular responses in the oligodendrocyte lineage.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

High cholesterol level is essential for myelin membrane growth

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Interferon-beta treatment decreases cholesterol plasma levels in multiple sclerosis patients

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Giant hepatic mitochondria: production in mice fed with cuprizone.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5286209

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

20 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14241

Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14241

7 January 2021

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14241

7 January 2021

Blood-brain barrier permeability during Cuprizone-induced demyelination. Implications for the pathogenesis of immune-mediated demyelinating diseases

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14241

7 January 2021

Cholesterol for synthesis of myelin is made locally, not imported into brain

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14241

7 January 2021

Identifiers

DOI

10.1038/NCOMMS14241

1 reference

19 September 2017

0 references

1 reference

19 September 2017

1 reference