Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. (Q40362310)

19 September 2017

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. (English)

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19 September 2017

Huasheng Lu

1

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19 September 2017

Clifton L Dalgard

2

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19 September 2017

Ahmed Mohyeldin

3

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19 September 2017

Thomas McFate

4

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19 September 2017

A Sasha Tait

5

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19 September 2017

Ajay Verma

6

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19 September 2017

language of work or name

English

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publication date

13 October 2005

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

280

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19 September 2017

51

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19 September 2017

41928-41939

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Targeting HIF-1 for cancer therapy

19 September 2017

1 reference

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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1 reference

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

21 January 2018

1 reference

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A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

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Oxygen sensing by HIF hydroxylases

21 January 2018

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The HAG mechanism: a molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases

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Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells

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Dysregulation of hypoxia inducible factor-1alpha in head and neck squamous cell carcinoma cell lines correlates with invasive potential.

21 January 2018

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

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Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases

21 January 2018

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Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

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Endogenous 2-oxoacids differentially regulate expression of oxygen sensors

21 January 2018

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Determination and comparison of specific activity of the HIF-prolyl hydroxylases

21 January 2018

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A fluorometric assay for the measurement of nitrite in biological samples.

21 January 2018

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Fluorescence analysis of the labile iron pool of mammalian cells.

21 January 2018

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Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity

21 January 2018

1 reference

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Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

21 January 2018

1 reference

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

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Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for

21 January 2018

1 reference

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Prolyl hydroxylase activity in tissue homogenates of annelids from deep sea hydrothermal vents

21 January 2018

1 reference

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Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate

21 January 2018

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

21 January 2018

1 reference

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Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells

21 January 2018

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Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

21 January 2018

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The role of ascorbate in the prolyl hydroxylase reaction

21 January 2018

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Selective promotion of ferrous ion-dependent lipid peroxidation in Ehrlich ascites tumor cells by histidine as compared with other amino acids.

21 January 2018

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Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro

21 January 2018

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

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Secretion of pyruvate. An antioxidant defense of mammalian cells

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Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer

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Vitamin C pharmacokinetics: implications for oral and intravenous use.

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Lactate: mirror and motor of tumor malignancy

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Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans

21 January 2018

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Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma

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21 January 2018

Identifiers

DOI

10.1074/JBC.M508718200

1 reference

19 September 2017

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