Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis (Q40374258)

19 September 2017

Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis (English)

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19 September 2017

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9

David M Holtzman

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19 September 2017

Jungsu Kim

1

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19 September 2017

Hong Jiang

2

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19 September 2017

Seonha Park

3

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19 September 2017

Adam E M Eltorai

4

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19 September 2017

Floy R Stewart

5

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19 September 2017

Hyejin Yoon

6

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19 September 2017

Jacob M Basak

7

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19 September 2017

Mary Beth Finn

8

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19 September 2017

language of work or name

English

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publication date

1 December 2011

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19 September 2017

Journal of Neuroscience

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19 September 2017

31

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19 September 2017

18007-18012

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49

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describes a project that uses

19 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3257514/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Alzheimer's disease: the challenge of the second century

22 September 2017

1 reference

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APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

22 September 2017

1 reference

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Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

22 September 2017

1 reference

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The role of apolipoprotein E in Alzheimer's disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

ApoE promotes the proteolytic degradation of Abeta

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

22 September 2017

1 reference

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Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

22 September 2017

1 reference

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Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

22 September 2017

1 reference

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

22 September 2017

1 reference

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A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

The presence of apoE4, not the absence of apoE3, contributes to AD pathology

22 September 2017

1 reference

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Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3.

22 September 2017

1 reference

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

ApoE4: is it the absence of good or the presence of bad?

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257514

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22159114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22159114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.3773-11.2011

1 reference

19 September 2017

1 reference

19 September 2017

1 reference