Early growth response 1 (Q4037945)

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mammalian protein found in Homo sapiens

early growth response protein 1
EGR-1
EGR1
NGFI-A
zinc finger protein 225
transcription factor ETR103
nerve growth factor-induced protein A
AT225
zinc finger protein Krox-24
transcription factor Zif268

Language	Label	Description	Also known as
English	Early growth response 1	mammalian protein found in Homo sapiens	early growth response protein 1 EGR-1 EGR1 NGFI-A zinc finger protein 225 transcription factor ETR103 nerve growth factor-induced protein A AT225 zinc finger protein Krox-24 transcription factor Zif268

Statements

1 reference

13 November 2019

UniProt protein ID

Zinc finger C2H2 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18146

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

early growth response transcription factors

1 reference

based on heuristic

inferred from protein domain or family

Early growth response protein 1, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

DNA-binding transcription factor activity

determination method

transcription cis-regulatory region binding

determination method

1 reference

8 April 2019

Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding

determination method

1 reference

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P18146

determination method

protein binding

determination method

3 references

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

histone acetyltransferase binding

determination method

1 reference

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

nucleic acid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

hemi-methylated DNA-binding

determination method

1 reference

8 April 2019

Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

double-stranded methylated DNA binding

determination method

1 reference

8 April 2019

Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

zinc ion binding

determination method

1 reference

8 April 2019

Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

promoter-specific chromatin binding

determination method

1 reference

8 April 2019

Mature human neutrophils constitutively express the transcription factor EGR-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

determination method

6 references

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P18146

determination method

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P18146

determination method

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P18146

determination method

3 January 2017

Mature human neutrophils constitutively express the transcription factor EGR-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P18146

determination method

3 January 2017

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P18146

determination method

3 January 2017

PTEN regulation by Akt-EGR1-ARF-PTEN axis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P18146

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Mature human neutrophils constitutively express the transcription factor EGR-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

determination method

7 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Mature human neutrophils constitutively express the transcription factor EGR-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

biological process

regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

cellular response to organic substance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

glomerular mesangial cell proliferation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

response to glucose

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

transcription by RNA polymerase II

determination method

1 reference

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

BMP signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

transcription, DNA-templated

determination method

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P18146

determination method

positive regulation of transcription, DNA-templated

determination method

response to insulin

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

interleukin-1-mediated signaling pathway

determination method

1 reference

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

cellular response to mycophenolic acid

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

T cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

type I interferon signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

positive regulation of glomerular metanephric mesangial cell proliferation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

cellular response to gamma radiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

regulation of transcription from RNA polymerase II promoter in response to hypoxia

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

skeletal muscle cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

cellular response to heparin

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

regulation of protein sumoylation

determination method

1 reference

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

negative regulation of canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

positive regulation of transcription by RNA polymerase II

determination method

5 references

8 April 2019

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

cellular response to interleukin-8

determination method

1 reference

8 April 2019

Mature human neutrophils constitutively express the transcription factor EGR-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

rhythmic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18146

determination method

Gene Atlas image

PBB GE EGR1 201694 s at fs.png
732 × 530; 11 KB

0 references

Zinc finger C2H2-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18146

Early growth response protein 1, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18146

Early growth response, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18146

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000239938

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000239938

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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