The clinical significance of p53 aberrations in human tumours (Q40381238)

20 September 2017

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title

The clinical significance of p53 aberrations in human tumours (English)

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20 September 2017

1

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20 September 2017

G Viale

2

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20 September 2017

publication date

1 January 1995

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20 September 2017

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20 September 2017

volume

427

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20 September 2017

issue

3

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20 September 2017

page(s)

229-241

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Association of P53 nuclear overexpression and tumor progression in carcinoma in situ of the bladder.

20 September 2017

cites work

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12 December 2020

p53 in node-negative breast carcinoma: an immunohistochemical study of epidemiologic risk factors, histologic features, and prognosis

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12 December 2020

Association of immunohistochemical staining for p53 with metastatic progression and poor survival in patients with renal cell carcinoma

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12 December 2020

p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry

1 reference

12 December 2020

Prognostic significance of human papillomavirus genomes (type-16, -18) and aberrant expression of p53 protein in human esophageal cancer

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12 December 2020

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

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12 December 2020

Polymerase chain reaction-based methods for the detection of mutations in oncogenes and tumor suppressor genes

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12 December 2020

An immunohistochemical study of p53 with correlations to histopathological parameters, c-erbB-2, proliferating cell nuclear antigen, and prognosis

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12 December 2020

Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression

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12 December 2020

Proliferating cell nuclear antigen and p53 expression as prognostic factors in T1-2M0 prostatic adenocarcinoma

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12 December 2020

Over-expression of p53 nuclear oncoprotein in transitional-cell bladder cancer and its prognostic value

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12 December 2020

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

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12 December 2020

High-risk human papillomavirus infections and overexpression of p53 protein as prognostic indicators in transitional cell carcinoma of the urinary bladder

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12 December 2020

c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer

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12 December 2020

Distinct regions of p53 have a differential role in transcriptional activation and repression functions

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12 December 2020

p53 status and the efficacy of cancer therapy in vivo

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12 December 2020

T antigen is bound to a host protein in SY40-transformed cells

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12 December 2020

The incidence of p53 mutations increases with progression of head and neck cancer

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12 December 2020

p53 gene mutations inside and outside of exons 5-8: the patterns differ in breast and other cancers.

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12 December 2020

Increased p53 protein content of colorectal tumours correlates with poor survival.

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12 December 2020

Apoptosis. Its significance in cancer and cancer therapy

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12 December 2020

The p53 tumour suppressor gene

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12 December 2020

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

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12 December 2020

Variations in immunohistochemical detection of p53 protein overexpression in cervical carcinomas with different antibodies and methods of detection

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12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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12 December 2020

Retinoblastoma and p53 gene expression related to relapse and survival in human breast cancer: an immunohistochemical study

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12 December 2020

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.

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12 December 2020

p53 tumor suppressor oncogene expression in squamous cell carcinoma of the hypopharynx

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12 December 2020

Prognostic value of p53 protein expression in breast carcinomas

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12 December 2020

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

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12 December 2020

Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma

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12 December 2020

Gastric cancer with p53 overexpression has high potential for metastasising to lymph nodes

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12 December 2020

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

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12 December 2020

Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients

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12 December 2020

Mutations of the p53 Gene as a Predictor of Poor Prognosis in Patients With Non-Small-Cell Lung Cancer

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12 December 2020

p53 expression and prognosis in gastric carcinoma

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12 December 2020

Clinical implications of the p53 tumor-suppressor gene

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12 December 2020

Prognostic significance of p53 immunoreactivity in adult patients with supratentorial fibrillary astrocytic neoplasms.

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12 December 2020

p53: from molecular mechanisms to prognosis in cancer

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12 December 2020

Mutations in the p53 gene occur in diverse human tumour types

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12 December 2020

p53 protein and vimentin in invasive ductal NOS breast carcinoma--relationship with survival and sites of metastases.

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12 December 2020

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

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12 December 2020

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer

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12 December 2020

Expression of p53 in oligodendrogliomas

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12 December 2020

Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor

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12 December 2020

William L. McGuire Memorial Symposium. The role and prognostic significance of p53 gene alterations in breast cancer

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12 December 2020

The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

p53 gene mutations and steroid receptor status in breast cancer. Clinicopathologic correlations and prognostic assessment

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12 December 2020

p53 as an independent prognostic marker in lymph node-negative breast cancer patients

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12 December 2020

Overexpression of p53 and HER-2/neu proteins as prognostic markers in early stage breast cancer

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12 December 2020

Efficacy of fluorescence-based PCR-SSCP for detection of point mutations

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12 December 2020

p53 protein immunostaining in routinely processed paraffin-embedded sections

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12 December 2020

Detection of p53 mutations by single-strand conformation polymorphisms (SSCP) gel electrophoresis. A comparative study of radioactive and nonradioactive silver-stained SSCP analysis

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12 December 2020

Detection and localization of single base changes by denaturing gradient gel electrophoresis

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12 December 2020

Detecting base pair substitutions in DNA fragments by temperature-gradient gel electrophoresis

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12 December 2020

Relationship among p53, stage, and prognosis of large bowel cancer

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12 December 2020

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

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12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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12 December 2020

Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis?

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12 December 2020

Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type

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12 December 2020

p53 alteration in gastric precancerous lesions.

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12 December 2020

p53 mutations in human cancers

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12 December 2020

p53 protein expression and prognosis in squamous cell carcinoma of the esophagus

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12 December 2020

bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas

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12 December 2020

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected].

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12 December 2020

Expression of p53 protein in colorectal cancer and its relationship to short-term prognosis

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12 December 2020

Overexpression and mutation of p53 in epithelial ovarian cancer

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12 December 2020

The p53 proto-oncogene can act as a suppressor of transformation

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12 December 2020

p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma

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12 December 2020

p53 protein expression in human breast carcinoma: relationship to expression of epidermal growth factor receptor, c-erbB-2 protein overexpression, and oestrogen receptor

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12 December 2020

Clinicopathologic significance of p53 immunostaining in adenocarcinoma of the breast

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12 December 2020

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes

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12 December 2020

p53 accumulation in ovarian carcinomas and its prognostic implications

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12 December 2020

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

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12 December 2020

A genetic model for colorectal tumorigenesis

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12 December 2020

p53 expression in human breast cancer related to survival and prognostic factors: an immunohistochemical study

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12 December 2020

Relationship of p53 overexpression and up-regulation of proliferating cell nuclear antigen with the clinical course of non-small cell lung cancer

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12 December 2020

Prognostic significance of p53 overexpression in gastric and colorectal carcinoma

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12 December 2020

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

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12 December 2020

A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma

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12 December 2020

Stepwise participation of p53 gene mutation during dedifferentiation of human thyroid carcinomas

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12 December 2020

Abnormal p53 immunoreactivity and prognosis in node-negative breast carcinomas with long-term follow-up

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12 December 2020

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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12 December 2020

Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation

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12 December 2020

Immunohistochemical detection of mutant p53-suppressor gene product in patients with breast cancer: influence on metastasis-free survival

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12 December 2020

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

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12 December 2020

Implications of the p53 tumor-suppressor gene in clinical oncology.

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12 December 2020

Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours

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12 December 2020

Overexpression of p53 protein in betel- and tobacco-related human oral dysplasia and squamous-cell carcinoma in India

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12 December 2020

Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma

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12 December 2020

The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model

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12 December 2020

Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and c-erbB-2 in endometrial carcinoma and correlation with survival and known predictors of survival

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12 December 2020

Association of p53 mutations with short survival in colorectal cancer

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12 December 2020

Prognostic significance of p53 protein expression and DNA ploidy in surgically treated non-small cell lung carcinomas

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12 December 2020

Prognostic significance of p53 overexpression in endometrial cancer

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12 December 2020

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

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12 December 2020

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

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12 December 2020

Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas.

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12 December 2020

p53 mutations have no additional prognostic value over stage in bladder cancer

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12 December 2020

Genetic steps in colorectal cancer.

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12 December 2020

p53 and c-myc expression in stage A1 prostatic adenocarcinoma: useful prognostic determinants?

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12 December 2020

Sensitivity of detection of heterozygous point mutations in p53 cDNAs by direct PCR sequencing

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12 December 2020

p53 protein expression in breast cancer as related to histopathological characteristics and prognosis

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12 December 2020

p53 function and dysfunction

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12 December 2020

Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck.

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12 December 2020

Immunocytochemical detection of p53 in human gliomas.

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12 December 2020

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene

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12 December 2020

Inhibition of p53 DNA binding by human papillomavirus E6 proteins

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12 December 2020

Accumulation of nuclear p53 and tumor progression in bladder cancer.

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12 December 2020

The relationship of p53 immunostaining to survival in carcinoma of the lung

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12 December 2020

Expression of p53 protein in gastric carcinomas. Association with histologic type and prognosis

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12 December 2020

Drug-target interactions: only the first step in the commitment to a programmed cell death?

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12 December 2020

Expression of proliferating cell nuclear antigen (PC10), p53 protein and c-erbB-2 in renal adenocarcinoma

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12 December 2020

Antibody for detecting p53 protein by immunohistochemistry in normal tissues

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12 December 2020

High prevalence of p53 protein overexpression in patients with esophageal cancer in Linxian, China and its relationship to progression and prognosis

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12 December 2020

Relative efficiency of denaturing gradient gel electrophoresis and single strand conformation polymorphism in the detection of mutations in exons 5 to 8 of the p53 gene

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12 December 2020

Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis

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12 December 2020

Expression of EGFR, HER-2/neu, P53, and PCNA in endometrioid, serous papillary, and clear cell endometrial adenocarcinomas

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12 December 2020

Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors

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12 December 2020

Significance of p53 expression as a prognostic factor in oesophageal squamous cell carcinoma

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12 December 2020

Prognostic factors in renal-cell carcinoma: immunohistochemical detection of p53 protein versus clinico-pathological parameters

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12 December 2020

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

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12 December 2020

Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity

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12 December 2020

PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA

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12 December 2020

Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer

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12 December 2020

Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma

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12 December 2020

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

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12 December 2020

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes

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12 December 2020

p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients.

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12 December 2020

p53 protein and c-erbB-2 protein (p185) expression in endometrial adenocarcinoma of endometrioid type. An immunohistochemical examination on paraffin sections

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12 December 2020

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

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12 December 2020

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

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12 December 2020

p53 protein expression in non-neoplastic lesions and benign and malignant neoplasms of soft tissue

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12 December 2020

Prognostic significance of p53 immunostaining in epithelial ovarian cancer.

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12 December 2020

Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer

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12 December 2020

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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12 December 2020

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

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12 December 2020

p53 immunoreactivity in inflammatory and neoplastic diseases of the uterine cervix.

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12 December 2020

p53 in colorectal cancer: clinicopathological correlation and prognostic significance

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12 December 2020

Methods in pathology. p53 expression in formalin-fixed, paraffin-embedded archival specimens of intrahepatic cholangiocarcinoma: retrieval of p53 antigenicity by microwave oven heating of tissue sections.

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12 December 2020

Immunohistochemical detection of p53 protein as a prognostic indicator in prostate cancer

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12 December 2020

High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early non-invasive lesio

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12 December 2020

Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis

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12 December 2020

Prognostic significance of K-ras mutations in colorectal carcinoma

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12 December 2020

Prognostic significance of TP53 alterations in breast carcinoma

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12 December 2020

Accumulation of wild type p53 protein in human astrocytomas

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12 December 2020

Value of P-glycoprotein, glutathione S-transferase pi, c-erbB-2, and p53 as prognostic factors in ovarian carcinomas

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12 December 2020

Gene therapy of cancer through restoration of tumor-suppressor functions?

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12 December 2020

Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer

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12 December 2020

Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer

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12 December 2020

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation

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12 December 2020

Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer

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12 December 2020

p53 alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes

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12 December 2020

How sensitive is PCR-SSCP?

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12 December 2020

Identifiers

DOI

10.1007/BF00203389

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Dimensions Publication ID

20 September 2017

1003974521

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