2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer (Q40382001)

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scientific article published on 23 August 2005

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English	2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer	scientific article published on 23 August 2005

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 September 2017

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer (English)

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Europe PubMed Central

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20 September 2017

pancreatic cancer

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based on heuristic

inferred from title

Marina Konopleva

2

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Marina Konopleva

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Europe PubMed Central

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20 September 2017

Michael Andreeff

13

object named as

Michael Andreeff

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20 September 2017

Teresa S McQueen

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object named as

Teresa McQueen

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20 September 2017

1

object named as

Ismael Samudio

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20 September 2017

3

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Numsen Hail

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object named as

Tadashi Honda

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20 September 2017

Gordon W Gribble

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object named as

Gordon W Gribble

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20 September 2017

author name string

Yue-Xi Shi

4

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Timothy Hsu

6

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20 September 2017

Randall Evans

7

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Michael Sporn

10

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Hiram F Gilbert

11

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Stephen Safe

12

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publication date

23 August 2005

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20 September 2017

Journal of Biological Chemistry

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20 September 2017

280

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20 September 2017

43

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20 September 2017

36273-36282

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20 September 2017

Pancreatic cancer

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https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Cytochrome c, glutathione, and the possible role of redox potentials in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Thiol-mediated apoptosis in prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid

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https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Thiol depletion induces lethal cell injury in cultured cardiomyocytes

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https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Redox regulation and signaling lipids in mitochondrial apoptosis

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https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Redox regulation of the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.

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https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

CDDO induces apoptosis via the intrinsic pathway in lymphoid cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.

1 reference

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21 January 2018

The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance

1 reference

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21 January 2018

BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.

1 reference

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21 January 2018

Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets

1 reference

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21 January 2018

A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Oxidative stress: role of mitochondria and protection by glutathione

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Mitochondria, the killer organelles and their weapons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

A novel triterpenoid induces transforming growth factor beta production by intraepithelial lymphocytes to prevent ileitis

1 reference

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21 January 2018

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-gamma expression

1 reference

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21 January 2018

Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in pancreatic cancer

1 reference

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21 January 2018

Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

1 reference

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21 January 2018

Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo

1 reference

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21 January 2018

Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and

1 reference

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21 January 2018

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.

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21 January 2018

Preferential targeting of apoptosis in tumor versus normal cells

1 reference

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21 January 2018

Irofulven induces apoptosis in breast cancer cells regardless of caspase-3 status

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21 January 2018

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

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21 January 2018

Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP kinase pathway

1 reference

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21 January 2018

Mitochondrial Glutathione: Importance and Transport

1 reference

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21 January 2018

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507518200

21 January 2018

Identifiers

10.1074/JBC.M507518200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

ResearchGate publication ID

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