mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells (Q40383681)

20 September 2017

mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells (English)

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20 September 2017

Li Hui

1

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20 September 2017

Vanessa Rodrik

2

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20 September 2017

Rafal M Pielak

3

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20 September 2017

Stefan Knirr

4

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20 September 2017

Yang Zheng

5

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20 September 2017

David A Foster

6

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20 September 2017

language of work or name

English

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publication date

18 August 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

43

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20 September 2017

35829-35835

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PI 3-kinase, Akt and cell survival

20 September 2017

1 reference

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Targeting mTOR-mediated survival signals in anticancer therapeutic strategies

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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Alternative phospholipase D/mTOR survival signal in human breast cancer cells

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Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells

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TOR, a central controller of cell growth

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

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PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

21 January 2018

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Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.

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The phosphoinositide 3-kinase pathway

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Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

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Does the ribosome translate cancer?

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Upstream and downstream of mTOR

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

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Creation of human tumour cells with defined genetic elements

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

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Identification of specific PP2A complexes involved in human cell transformation

21 January 2018

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Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

21 January 2018

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Control of protein phosphatase 2A by simian virus 40 small-t antigen

21 January 2018

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PP2A fulfills its promises as tumor suppressor: which subunits are important?

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Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2.

21 January 2018

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Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts

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Phospholipase D confers rapamycin resistance in human breast cancer cells

21 January 2018

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Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

21 January 2018

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Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity

21 January 2018

1 reference

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The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

21 January 2018

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Role for phospholipase D in receptor-mediated endocytosis

21 January 2018

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Relevance of breast cancer cell lines as models for breast tumours: an update

21 January 2018

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Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression

21 January 2018

1 reference

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

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Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

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The Hallmarks of Cancer

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Will mTOR inhibitors make it as cancer drugs?

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Translational control of the antiapoptotic function of Ras.

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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

21 January 2018

1 reference

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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21 January 2018

Identifiers

DOI

10.1074/JBC.M504192200

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20 September 2017

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