Neuroprotective effects of virally delivered HSPs in experimental stroke (Q40389152)

20 September 2017

Neuroprotective effects of virally delivered HSPs in experimental stroke (English)

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20 September 2017

Louise van der Weerd

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Mark Lythgoe

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Mark F Lythgoe

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author name string

Romina Aron Badin

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20 September 2017

David L Thomas

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20 September 2017

David G Gadian

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20 September 2017

David S Latchman

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20 September 2017

1 March 2006

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Journal of Cerebral Blood Flow & Metabolism

20 September 2017

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20 September 2017

26

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20 September 2017

3

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20 September 2017

371-381

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The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death

20 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Over-expression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Overexpression of hsp70i facilitates reactivation of intracellular proteins in neurones and protects them from denaturing stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Hsp27 negatively regulates cell death by interacting with cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Ischemic tolerance and endogenous neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Size matters: of the small HSP27 and its large oligomers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Differential induction of mRNA species encoding several classes of stress proteins following focal cerebral ischemia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

High efficiency gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Regional difference of HSP70 and HSC70 heat shock mRNA inductions in rat hippocampus after transient global ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Gene delivery and gene therapy with herpes simplex virus-based vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Protective effect of heat shock proteins in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

21 January 2018

The heat-shock proteins

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Reversible middle cerebral artery occlusion without craniectomy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

The chaperone function of hsp70 is required for protection against stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Hsp27 as a negative regulator of cytochrome C release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Heat-shock protein 70 antagonizes apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Stress proteins in neural cells: functional roles in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

A new puffing pattern induced by temperature shock and DNP in drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Heat-shock protein protection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Maintenance and synthesis of proteins for an anucleate axon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Administration of Hsp70 in vivo inhibits motor and sensory neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Heat shock-like protein is transferred from glia to axon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Gene transfer using a disabled herpes virus vector containing the EMCV IRES allows multiple gene expression in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Heat shock protein 27 delays Ca2+-induced cell death in a caspase-dependent and -independent manner in rat retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Hsp27 and axonal growth in adult sensory neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Engineering herpes simplex virus vectors for CNS applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

The neuroprotective potential of heat shock protein 70 (HSP70).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Heat shock protein 27 stimulates recovery of RNA and protein synthesis following a heat shock

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Ischemic tolerance in the brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Heat shock protein 27: developmental regulation and expression after peripheral nerve injury.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

HSP27 inhibits cytochrome c-dependent activation of procaspase-9.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Induction of HSP90 alpha heat shock mRNA after transient global ischemia in gerbil hippocampus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Heat shock proteins hsp90 and hsp70 protect neuronal cells from thermal stress but not from programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Transfection-mediated expression of human Hsp70i protects rat dorsal root ganglian neurones and glia from severe heat stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Trigeminal ganglion neurons are protected by the heat shock proteins hsp70 and hsp90 from thermal stress but not from programmed cell death following nerve growth factor withdrawal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600190

7 January 2021

Identifiers

DOI

10.1038/SJ.JCBFM.9600190

1 reference

20 September 2017

1 reference