GRB2 associated binding protein 2 (Q4039104)

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mammalian protein found in Homo sapiens

• GAB2
• Grb2-associated binder 2
• pp100
• growth factor receptor bound protein 2-associated protein 2
• GRB2-associated-binding protein 2
• GAB2 protein, human

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Language	Label	Description	Also known as
English	GRB2 associated binding protein 2	mammalian protein found in Homo sapiens	GAB2 Grb2-associated binder 2 pp100 growth factor receptor bound protein 2-associated protein 2 GRB2-associated-binding protein 2 GAB2 protein, human

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UQC2

part of

PH-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UQC2

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UQC2

encoded by

GAB2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UQC2

molecular function

phosphatidylinositol-3,4,5-trisphosphate binding

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

ISS

transmembrane receptor protein tyrosine kinase adaptor activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IDA

phosphatidylinositol-3,4-bisphosphate binding

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

ISS

protein binding

determination method

IPI

9 references

retrieved

8 April 2019

stated in

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

retrieved

8 April 2019

stated in

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

retrieved

8 April 2019

stated in

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

retrieved

8 April 2019

stated in

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

retrieved

8 April 2019

stated in

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

retrieved

8 April 2019

stated in

A human MAP kinase interactome

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

retrieved

8 April 2019

stated in

Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

retrieved

8 April 2019

stated in

Charting the molecular network of the drug target Bcr-Abl

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IPI

1-phosphatidylinositol-3-kinase activity

determination method

TAS

1 reference

retrieved

21 June 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQC2&geneProductId=UniProtKB:Q9UQC2

determination method

TAS

cell component

cytosol

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

TAS

plasma membrane

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IEA

retrieved

8 April 2019

stated in

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IDA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IDA

membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IEA

cytoplasm

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IEA

retrieved

8 April 2019

stated in

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IDA

biological process

positive regulation of mast cell degranulation

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

ISS

osteoclast differentiation

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IMP

phosphatidylinositol-mediated signaling

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

ISS

positive regulation of cell population proliferation

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

GOA

curator

UniProt

UniProt protein ID

Q9UQC2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IDA

Fc-epsilon receptor signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

TAS

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

IEA

axon guidance

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

TAS

cytokine-mediated signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQC2

determination method

TAS

phosphatidylinositol-3-phosphate biosynthetic process

determination method

IEA

1 reference

retrieved

21 June 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQC2&geneProductId=UniProtKB:Q9UQC2

determination method

IEA

Gene Atlas image

PBB GE GAB2 203853 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

pleckstrin homology domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UQC2

Identifiers

MeSH descriptor ID

C490895

subject named as

GAB2 protein, human

0 references

RefSeq protein ID

NP_036428

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9846

NP_536739

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9846

XP_006718816

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9846

XP_011543710

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9846

XP_024304550

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9846

UniProt protein ID

Q9UQC2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UQC2

Ensembl protein ID

ENSP00000343959

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000343959

ENSP00000354952

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000354952

ENSP00000431868

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000431868

ENSP00000433762

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000433762

PDB structure ID

2VWF

1 reference

stated in

UniProt

UniProt protein ID

Q9UQC2

retrieved

9 August 2016

language of work or name

English

2W0Z

1 reference

stated in

UniProt

UniProt protein ID

Q9UQC2

retrieved

9 August 2016

language of work or name

English

5EXA

1 reference

stated in

UniProt

UniProt protein ID

Q9UQC2

retrieved

9 August 2016

language of work or name

English

5EWZ

1 reference

stated in

UniProt

UniProt protein ID

Q9UQC2

retrieved

9 August 2016

language of work or name

English

UMLS CUI

C0387800

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q4039104&oldid=2022904773"