NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses (Q40399903)

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scientific article published on 21 December 2016

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English	NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses	scientific article published on 21 December 2016

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scholarly article

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20 September 2017

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses (English)

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8 June 2020

Luis Martinez-Sobrido

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Marta L DeDiego

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21 December 2016

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Journal of Virology

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NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.

1 reference

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Structural basis for suppression of a host antiviral response by influenza A virus

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The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells

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Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens

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IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein

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Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus

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NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I

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Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway.

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22 September 2017

Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles

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Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein

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Imparting temperature sensitivity and attenuation in ferrets to A/Puerto Rico/8/34 influenza virus by transferring the genetic signature for temperature sensitivity from cold-adapted A/Ann Arbor/6/60.

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Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS

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Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60.

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Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.

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Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems

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Sequential addition of temperature-sensitive missense mutations into the PB2 gene of influenza A transfectant viruses can effect an increase in temperature sensitivity and attenuation and permits the rational design of a genetically engineered live

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12 December 2020

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10.1128/JVI.01930-16

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8 June 2020

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8 June 2020

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