Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques. (Q40405593)

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scientific article published on August 2005

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English	Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques.	scientific article published on August 2005

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scholarly article

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13 January 2020

Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques (English)

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13 January 2020

transmembrane protein

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1

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13 January 2020

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Melissa L Gomez

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13 January 2020

Erik Pacyniak

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13 January 2020

Lisa M Gomez

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13 January 2020

Sarah H Inbody

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13 January 2020

Ellyn R Mulcahy

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13 January 2020

Nathan Culley

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13 January 2020

David M Pinson

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Michael F Powers

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Scott W Wong

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Edward B Stephens

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1 August 2005

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20 September 2017

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13 January 2020

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13 January 2020

The structure of the HIV-1 Vpu ion channel: modelling and simulation studies.

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Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu.

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Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages

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Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors

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Ion channels formed by HIV-1 Vpu: a modelling and simulation study

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Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems

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Vpu: a multifunctional protein that enhances the pathogenesis of human immunodeficiency virus type 1.

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Pathogenesis of SIVmac infection in Chinese and Indian rhesus macaques: effects of splenectomy on virus burden

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The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release

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Derivation and biological characterization of a molecular clone of SHIV(KU-2) that causes AIDS, neurological disease, and renal disease in rhesus macaques

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Fatal immunopathogenesis by SIV/HIV-1 (SHIV) containing a variant form of the HIV-1SF33 env gene in juvenile and newborn rhesus macaques

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Comparison of Vpu sequences from diverse geographical isolates of HIV type 1 identifies the presence of highly variable domains, additional invariant amino acids, and a signature sequence motif common to subtype C isolates

1 reference

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7 January 2021

A molecular clone of simian-human immunodeficiency virus (DeltavpuSHIV(KU-1bMC33)) with a truncated, non-membrane-bound vpu results in rapid CD4(+) T cell loss and neuro-AIDS in pig-tailed macaques

1 reference

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7 January 2021

Identification of a region within the cytoplasmic domain of the subtype B Vpu protein of human immunodeficiency virus type 1 (HIV-1) that is responsible for retention in the golgi complex and its absence in the Vpu protein from a subtype C HIV-1.

1 reference

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7 January 2021

Three-dimensional Structure of the Channel-forming Trans-membrane Domain of Virus Protein “u” (Vpu) from HIV-1

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Phosphorylation of both phosphoacceptor sites in the HIV-1 Vpu cytoplasmic domain is essential for Vpu-mediated ER degradation of CD4

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Complete nucleotide sequence of the AIDS virus, HTLV-III

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The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus

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The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif

1 reference

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7 January 2021

Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells

1 reference

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Two long terminal repeat circles and persistent HIV-1 replication

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Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy

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A simian human immunodeficiency virus with a nonfunctional Vpu (deltavpuSHIV(KU-1bMC33)) isolated from a macaque with neuroAIDS has selected for mutations in env and nef that contributed to its pathogenic phenotype

1 reference

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7 January 2021

The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.04.038

7 January 2021

Nucleotide substitutions in the long terminal repeat are not required for development of neurovirulence by simian immunodeficiency virus strain mac.

1 reference

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7 January 2021

Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques

1 reference

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Structural and functional analysis of the membrane-spanning domain of the human immunodeficiency virus type 1 Vpu protein

1 reference

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Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production

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Evaluation of the presence of 2-LTR HIV-1 unintegrated DNA as a simple molecular predictor of disease progression.

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Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

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Chimeric simian/human immunodeficiency virus that causes progressive loss of CD4+ T cells and AIDS in pig-tailed macaques

1 reference

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based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.04.038

7 January 2021

based on heuristic

inferred from DOI database lookup

CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.04.038

7 January 2021

based on heuristic

inferred from DOI database lookup

Circular forms of unintegrated human immunodeficiency virus type 1 DNA and high levels of viral protein expression: association with dementia and multinucleated giant cells in the brains of patients with AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.04.038

7 January 2021

based on heuristic

inferred from DOI database lookup

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