Murine models of neoplasia: functional analysis of the tumour suppressor genes Rb-1 and p53. (Q40410709)

20 September 2017

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title

Murine models of neoplasia: functional analysis of the tumour suppressor genes Rb-1 and p53. (English)

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20 September 2017

1

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20 September 2017

publication date

1 June 1995

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Cancer and Metastasis Reviews

20 September 2017

published in

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20 September 2017

volume

14

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20 September 2017

issue

2

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20 September 2017

page(s)

125-148

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p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

20 September 2017

cites work

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12 December 2020

Retinoma: spontaneous regression of retinoblastoma or benign manifestation of the mutation?

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12 December 2020

Mutation and cancer: statistical study of retinoblastoma

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12 December 2020

Amplification of a gene encoding a p53-associated protein in human sarcomas

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12 December 2020

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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12 December 2020

Social controls on cell survival and cell death

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12 December 2020

Retinoblastoma protein and the cell cycle.

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12 December 2020

T antigen is bound to a host protein in SY40-transformed cells

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12 December 2020

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

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12 December 2020

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences

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12 December 2020

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

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12 December 2020

Double labelling with bromodeoxyuridine and [3H]-thymidine of proliferative cells in small intestinal epithelium in steady state and after irradiation

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12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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12 December 2020

Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen

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12 December 2020

p53 mutations increase resistance to ionizing radiation

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12 December 2020

Effects of heterozygosity for the Rb-1t19neo allele in the mouse

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12 December 2020

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

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12 December 2020

Enhanced proliferative potential in culture of cells from p53-deficient mice

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12 December 2020

Parental origin of mutations of the retinoblastoma gene

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12 December 2020

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

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12 December 2020

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

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12 December 2020

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

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12 December 2020

Cell cycle-specific association of E2F with the p130 E1A-binding protein

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12 December 2020

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

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12 December 2020

Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

1 reference

12 December 2020

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

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12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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12 December 2020

Mutations in the p53 gene occur in diverse human tumour types

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12 December 2020

Tumor spectrum analysis in p53-mutant mice

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12 December 2020

Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats.

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12 December 2020

Cancer. p53, guardian of the genome

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12 December 2020

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

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12 December 2020

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

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12 December 2020

S-antigen and rod-opsin immunoreactions in midline brain neoplasms of transgenic mice: similarities to pineal cell tumors and certain medulloblastomas in man.

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12 December 2020

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

Genetic background alters the spectrum of tumors that develop in p53-deficient mice

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12 December 2020

Peripheral T lymphocyte depletion by apoptosis after CD4 ligation in vivo: selective loss of CD44- and 'activating' memory T cells

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12 December 2020

Cooperative tumorigenic effects of germline mutations in Rb and p53

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12 December 2020

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

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12 December 2020

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance

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12 December 2020

Structural rearrangement of the retinoblastoma gene in human breast carcinoma

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12 December 2020

p53-dependent apoptosis suppresses tumor growth and progression in vivo

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12 December 2020

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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12 December 2020

Point mutational inactivation of the retinoblastoma antioncogene

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12 December 2020

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins

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12 December 2020

Human retinoblastoma susceptibility gene: cloning, identification, and sequence

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12 December 2020

p53 mutations in human cancers

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12 December 2020

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

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12 December 2020

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E

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12 December 2020

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

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12 December 2020

Inactivation of the retinoblastoma susceptibility gene in human breast cancers

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12 December 2020

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

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12 December 2020

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents

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12 December 2020

Regulation of T lymphocyte apoptosis. Signals for the antagonism between activation- and glucocorticoid-induced death

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12 December 2020

p53 and E2F-1 cooperate to mediate apoptosis

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12 December 2020

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

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12 December 2020

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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12 December 2020

The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells

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12 December 2020

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

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12 December 2020

Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate: correlation between chromosomal damage and conversion ('stage I of tumor promotion') in vivo

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12 December 2020

Cell cycle. Dams and sluices.

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12 December 2020

The role of the p53 and Rb-1 genes in cancer, development and apoptosis

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12 December 2020

Inhibition of mammalian cell DNA synthesis by ionizing radiation

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12 December 2020

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

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12 December 2020

Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma

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12 December 2020

Participation of p53 protein in the cellular response to DNA damage

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12 December 2020

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein

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12 December 2020

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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12 December 2020

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

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12 December 2020

Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma.

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12 December 2020

Effect of ionizing radiation and topoisomerase II inhibitors on DNA synthesis in mammalian cells

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12 December 2020

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

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12 December 2020

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene

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12 December 2020

Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac.

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12 December 2020

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.

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12 December 2020

Retinoblastoma in transgenic mice

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12 December 2020

Unraveling the function of the retinoblastoma gene

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12 December 2020

A comprehensive study of the radiobiological response of the murine (BDF1) small intestine

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12 December 2020

Requirement for a functional Rb-1 gene in murine development

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12 December 2020

Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells

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12 December 2020

Immortalized retinal neurons derived from SV40 T-antigen-induced tumors in transgenic mice.

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12 December 2020

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

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12 December 2020

Effects of an Rb mutation in the mouse

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12 December 2020

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice

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12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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12 December 2020

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice

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12 December 2020

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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12 December 2020

Different tumor-derived p53 mutants exhibit distinct biological activities

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12 December 2020

Apoptosis: Mechanisms and Roles in Pathology

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12 December 2020

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

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12 December 2020

Preferential germline mutation of the paternal allele in retinoblastoma

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12 December 2020

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

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12 December 2020

Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses

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12 December 2020

Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.

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12 December 2020

Tumor suppressor genes

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12 December 2020

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice

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12 December 2020

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

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12 December 2020

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

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12 December 2020

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

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12 December 2020

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

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12 December 2020

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

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12 December 2020

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

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12 December 2020

Identifiers

DOI

10.1007/BF00665796

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Dimensions Publication ID

20 September 2017

1038893228

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