Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies (Q40427406)

20 September 2017

Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies (English)

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20 September 2017

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Kah Fai Chan

1

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20 September 2017

Wahyu Shahreel

2

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20 September 2017

Corrine Wan

3

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20 September 2017

Gavin Teo

4

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20 September 2017

Noor Hayati

5

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20 September 2017

Shi Jie Tay

6

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20 September 2017

Wen Han Tong

7

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20 September 2017

Yuansheng Yang

8

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20 September 2017

Pauline M Rudd

9

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20 September 2017

Peiqing Zhang

10

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20 September 2017

Zhiwei Song

11

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20 September 2017

16 October 2015

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20 September 2017

Biotechnology Journal

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20 September 2017

11

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20 September 2017

399-414

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20 September 2017

3

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The structure of a human type III Fcgamma receptor in complex with Fc

20 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500331

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500331

In vitro and in vivo characterization of MDX-1401 for therapy of malignant lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201500331

Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IgG1 Is independent of FcgammaRIIIa functional polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Development of orally active inhibitors of protein and cellular fucosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Fucose: biosynthesis and biological function in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

An improved zinc-finger nuclease architecture for highly specific genome editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Targeting DNA double-strand breaks with TAL effector nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A TALE nuclease architecture for efficient genome editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Breaking the code of DNA binding specificity of TAL-type III effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A simple cipher governs DNA recognition by TAL effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A library of TAL effector nucleases spanning the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

RNA-guided human genome engineering via Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Identification of functional elements of the GDP-fucose transporter SLC35C1 using a novel Chinese hamster ovary mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Genetic and structural characterization of the avirulence gene avrBs3 from Xanthomonas campestris pv. vesicatoria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A transcription activator-like effector toolbox for genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A rapid and general assay for monitoring endogenous gene modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

RCA-I-resistant CHO mutant cells have dysfunctional GnT I and expression of normal GnT I in these mutants enhances sialylation of recombinant erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

The Golgi CMP-sialic acid transporter: A new CHO mutant provides functional insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Glycomics profiling of Chinese hamster ovary cell glycosylation mutants reveals N-glycans of a novel size and complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Erythropoietin produced in a human cell line (Dynepo) has significant differences in glycosylation compared with erythropoietins produced in CHO cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Validated zinc finger protein designs for all 16 GNN DNA triplet targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Carbohydrate binding specificity of a fucose-specific lectin from Aspergillus oryzae: a novel probe for core fucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A systematic approach to protein glycosylation analysis: a path through the maze

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

O-fucosylation of notch occurs in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

The generation of zinc finger proteins by modular assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

FLASH assembly of TALENs for high-throughput genome editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201500331

21 January 2018

Identifiers

DOI

10.1002/BIOT.201500331

1 reference

20 September 2017

1 reference