ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. (Q40428511)

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11 January 2020

title

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity (English)

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11 January 2020

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7

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11 January 2020

Hidenori Ichijō

10

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11 January 2020

Takuya Noguchi

3

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11 January 2020

Hideki Nishitoh

5

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11 January 2020

Kohsuke Takeda

9

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11 January 2020

author name string

Atsushi Matsuzawa

1

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11 January 2020

Kaoru Saegusa

2

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11 January 2020

Chiharu Sadamitsu

4

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11 January 2020

Shigenori Nagai

6

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11 January 2020

Kunihiro Matsumoto

8

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11 January 2020

language of work or name

English

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publication date

1 May 2005

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11 January 2020

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11 January 2020

volume

6

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11 January 2020

page(s)

587-592

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11 January 2020

issue

6

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Toll-like receptors and innate immunity

11 January 2020

cites work

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7 January 2021

Toll-like receptors: critical proteins linking innate and acquired immunity

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7 January 2021

Drosophila innate immunity: an evolutionary perspective

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7 January 2021

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

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7 January 2021

IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis

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7 January 2021

Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment

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7 January 2021

A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity

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7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

7 January 2021

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

1 reference

7 January 2021

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

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7 January 2021

ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction

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7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

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7 January 2021

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

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7 January 2021

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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7 January 2021

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

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7 January 2021

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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7 January 2021

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

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7 January 2021

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

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7 January 2021

Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer

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7 January 2021

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

1 reference

7 January 2021

Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway

1 reference

7 January 2021

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

1 reference

7 January 2021

p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts

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7 January 2021

Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression

1 reference

7 January 2021

ASK1 is essential for JNK/SAPK activation by TRAF2

1 reference

7 January 2021

Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B

1 reference

7 January 2021

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

1 reference

7 January 2021

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

1 reference

7 January 2021

Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

1 reference

7 January 2021

Novel strategies for the treatment of sepsis

1 reference

7 January 2021

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

1 reference

7 January 2021

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

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7 January 2021

TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

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7 January 2021

Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species

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7 January 2021

Identifiers

DOI

10.1038/NI1200

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11 January 2020

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