Human triglyceride-rich lipoproteins impair glucose metabolism and insulin signalling in L6 skeletal muscle cells independently of non-esterified fatty acid levels. (Q40450700)

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scientific article published on 4 March 2005

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English	Human triglyceride-rich lipoproteins impair glucose metabolism and insulin signalling in L6 skeletal muscle cells independently of non-esterified fatty acid levels.	scientific article published on 4 March 2005

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scholarly article

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9 January 2020

Human triglyceride-rich lipoproteins impair glucose metabolism and insulin signalling in L6 skeletal muscle cells independently of non-esterified fatty acid levels (English)

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9 January 2020

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skeletal muscle cell

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4

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9 January 2020

Lukas Alfons Huber

7

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9 January 2020

author name string

M T Pedrini

1

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9 January 2020

M Kranebitter

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9 January 2020

A Niederwanger

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9 January 2020

J Engl

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9 January 2020

P Debbage

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9 January 2020

J R Patsch

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9 January 2020

publication date

4 March 2005

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9 January 2020

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9 January 2020

48

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9 January 2020

4

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9 January 2020

756-766

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9 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-005-1684-8

0 references

Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Aortic accumulation and plasma clearance of beta-VLDL and HDL: effects of diet-induced hypercholesterolemia in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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A Computational Approach to Edge Detection

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https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Cellular interactions of lipoproteins with the vascular endothelium: endocytosis and transcytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Skeletal muscle triglyceride levels are inversely related to insulin action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Intimal retention of cholesterol derived from apolipoprotein B100- and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe heritable hyperlipidemic rabbits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Zonal ultracentrifugation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall--evidence that plaque cholesterol may be derived from post-prandial lipoproteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Arterial intimal retention of pro-atherogenic lipoproteins in insulin deficient rabbits and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Metabolic control of beta-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Isolation of subfractions of human very low density lipoproteins by zonal ultracentrifugation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Intravenous lipid emulsions: removal mechanisms as compared to chylomicrons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Postprandial lipemia. A key for the conversion of high density lipoprotein2 into high density lipoprotein3 by hepatic lipase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

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Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low-density lipoprotein, high-density lipoprotein, and albumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Chylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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IDL, VLDL, chylomicrons and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

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Insulin-secreting beta-cell dysfunction induced by human lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of hypertriglyceridemic very low density lipoproteins and their remnants by HepG2 cells: the role of lipoprotein lipase, hepatic triglyceride lipase, and cell surface proteoglycans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arterial fatty lesions have increased uptake of chylomicron remnants but not low-density lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance of lipoprotein remnant particles in adipose tissue and muscle in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of in vitro lipolysis by tetrahydrolipstatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic free fatty acid infusion in rats results in insulin resistance but no alteration in insulin-responsive glucose transporter levels in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saturated fatty acid-induced insulin resistance in rat adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of intramuscular lipid in insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15747109

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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