De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine. (Q40453633)

20 September 2017

De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine. (English)

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20 September 2017

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Masahiro Oka

1

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20 September 2017

Amy M Meacham

2

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20 September 2017

Takashi Hamazaki

3

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20 September 2017

Nemanja Rodić

4

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20 September 2017

Lung-Ji Chang

5

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20 September 2017

Naohiro Terada

6

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20 September 2017

language of work or name

English

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publication date

1 April 2005

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20 September 2017

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20 September 2017

24

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20 September 2017

19

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20 September 2017

3091-3099

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208540

20 September 2017

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cites work

Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

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7 January 2021

An essential role for DNA methyltransferase DNMT3B in cancer cell survival

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7 January 2021

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer

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7 January 2021

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation

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7 January 2021

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

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7 January 2021

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

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7 January 2021

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7 January 2021

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

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7 January 2021

High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer

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7 January 2021

Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells

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7 January 2021

Induction of Tumors in Mice by Genomic Hypomethylation

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7 January 2021

Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro

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7 January 2021

Increased cytosine DNA-methyltransferase activity during colon cancer progression

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7 January 2021

Self-inactivating lentiviral vectors with U3 and U5 modifications.

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7 January 2021

Cellular differentiation, cytidine analogs and DNA methylation

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7 January 2021

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208540

7 January 2021

1-beta-D-arabinosylcytosine and 5-azacytidine induce internucleosomal DNA fragmentation and cell death in thymocytes

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7 January 2021

The role of DNA methylation in cancer genetic and epigenetics

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7 January 2021

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

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7 January 2021

Increased DNA methyltransferase expression in leukaemia

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7 January 2021

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

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7 January 2021

The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine

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7 January 2021

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

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7 January 2021

Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

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7 January 2021

Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

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7 January 2021

Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis

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7 January 2021

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

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7 January 2021

5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms

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7 January 2021

Proliferating cell nuclear antigen is required for DNA excision repair

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7 January 2021

DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras.

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7 January 2021

Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

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7 January 2021

Cloning, expression and chromosome locations of the human DNMT3 gene family

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7 January 2021

RNA 3' readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy

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7 January 2021

5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208540

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Dimensions Publication ID

20 September 2017

1033473497

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Fatcat ID

release_s3s5y4hcxnchnn4a4milq2jc4e

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/s3s5y4hcxnchnn4a4milq2jc4e

24 November 2022

mapped directly with Wikidata item

1 reference