Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha. (Q40477164)

20 September 2017

Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha. (English)

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20 September 2017

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C Geisler

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author name string

C Brender

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20 September 2017

P Lovato

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V H Sommer

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A-M Mathiesen

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M Wasik

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N Ødum

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1 February 2005

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209-213

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403610

20 September 2017

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cites work

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Stat3 activation is required for cellular transformation by v-src

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Stat3 activation by Src induces specific gene regulation and is required for cell transformation

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Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

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21 January 2018

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

21 January 2018

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Gigantism in mice lacking suppressor of cytokine signalling-2

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SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma

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Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms

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Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors

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The tumor suppressor activity of SOCS-1.

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The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

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STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

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Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells

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Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

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Establishment of two continuous T-cell strains from a single plaque of a patient with mycosis fungoides

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Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells

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Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.

21 January 2018

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

21 January 2018

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Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

21 January 2018

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Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

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Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice

21 January 2018

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Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

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A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.

21 January 2018

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In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3.

21 January 2018

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Suppressors of cytokine signalling (SOCS) in the immune system

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403610

inferred from DOI database lookup

7 January 2021

based on heuristic

Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403610

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.LEU.2403610

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Dimensions Publication ID

20 September 2017

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