Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor. (Q40477773)

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6 January 2020

title

Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor (English)

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5

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Vinay K. Pathak

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Sonja Hess

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author name string

Kerry L Williams

1

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Yijun Zhang

2

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Nick Shkriabai

3

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Rajeshri G Karki

4

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Nana Kotrikadze

6

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Stuart F J Le Grice

8

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Robert Craigie

9

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Mamuka Kvaratskhelia

11

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language of work or name

English

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publication date

22 December 2004

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Journal of Biological Chemistry

6 January 2020

published in

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volume

280

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issue

9

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page(s)

7949-7955

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Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

6 January 2020

cites work

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Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

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Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

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The DNA-binding domain of HIV-1 integrase has an SH3-like fold

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Solution structure of the DNA binding domain of HIV-1 integrase

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Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

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HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching

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Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase

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Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization

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Retroviral integrase inhibitors year 2000: update and perspectives

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Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase.

21 January 2018

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New class of HIV integrase inhibitors that block viral replication in cell culture

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Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

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HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

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Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

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A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

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Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design

21 January 2018

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Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

21 January 2018

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Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

21 January 2018

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Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction

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A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes

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A quantitative assay for HIV DNA integration in vivo

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Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions

21 January 2018

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21 January 2018

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Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking

21 January 2018

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Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.

21 January 2018

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Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex

21 January 2018

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Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking.

21 January 2018

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The solution structure of the Sac7d/DNA complex: a small-angle X-ray scattering study

21 January 2018

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Identification of a nucleotide binding site in HIV-1 integrase

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Identifiers

DOI

10.1074/JBC.M413579200

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6 January 2020

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