FLT3/ITD mutation signaling includes suppression of SHP-1. (Q40485872)

20 September 2017

FLT3/ITD mutation signaling includes suppression of SHP-1. (English)

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20 September 2017

Peili Chen

1

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20 September 2017

Mark Levis

2

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20 September 2017

Patrick Brown

3

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20 September 2017

Kyu-Tae Kim

4

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20 September 2017

Jeffrey Allebach

5

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20 September 2017

Donald Small

6

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20 September 2017

language of work or name

English

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publication date

1 December 2004

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

7

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20 September 2017

5361-5369

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Oncogenic kinase signalling

20 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M411974200

Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.

21 January 2018

1 reference

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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

21 January 2018

1 reference

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STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

FLT3: ITDoes matter in leukemia

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411974200

The roles of FLT3 in hematopoiesis and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

21 January 2018

1 reference

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FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

21 January 2018

1 reference

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A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

21 January 2018

1 reference

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FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

21 January 2018

1 reference

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In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

21 January 2018

1 reference

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Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

21 January 2018

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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

21 January 2018

1 reference

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Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

21 January 2018

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PTEN: from pathology to biology

21 January 2018

1 reference

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 January 2018

1 reference

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Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains

21 January 2018

1 reference

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Anticancer activity of sodium stibogluconate in synergy with IFNs

21 January 2018

1 reference

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

21 January 2018

1 reference

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Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

21 January 2018

1 reference

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

21 January 2018

1 reference

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Molecular interactions of SHP1 and SHP2 in IL-3-signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

21 January 2018

1 reference

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Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias : combination analysis with cDNA expression array and tissue microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

21 January 2018

1 reference

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Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

21 January 2018

1 reference

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Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage

21 January 2018

1 reference

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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

Abnormal splicing of SHP-1 protein tyrosine phosphatase in human T cells. Implications for lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411974200

21 January 2018

Identifiers

DOI

10.1074/JBC.M411974200

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20 September 2017

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