Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor (Q40490382)

21 September 2017

Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor (English)

1 reference

21 September 2017

6

Thomas J Gardella

1 reference

21 September 2017

Naoto Shimizu

1

1 reference

21 September 2017

Thomas Dean

2

1 reference

21 September 2017

Janet C Tsang

3

1 reference

21 September 2017

Ashok Khatri

4

1 reference

21 September 2017

John T Potts

5

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21 September 2017

language of work or name

English

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publication date

17 November 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

280

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21 September 2017

3

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21 September 2017

1797-1807

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The physiology of parathyroid hormone-related protein

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Evaluating the signal transduction mechanism of the parathyroid hormone 1 receptor. Effect of receptor-G-protein interaction on the ligand binding mechanism and receptor conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Residue 19 of the parathyroid hormone (PTH) modulates ligand interaction with the juxtamembrane region of the PTH-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Multiple sites of contact between the carboxyl-terminal binding domain of PTHrP-(1--36) analogs and the amino-terminal extracellular domain of the PTH/PTHrP receptor identified by photoaffinity cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Molecular properties of the PTH/PTHrP receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Chimeric human calcitonin and glucagon receptors reveal two dissociable calcitonin interaction sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Photoaffinity labeling demonstrates physical contact between vasoactive intestinal peptide and the N-terminal ectodomain of the human VPAC1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Enhanced activity in parathyroid hormone-(1-14) and -(1-11): novel peptides for probing ligand-receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Parathyroid hormone (PTH)-(1-14) and -(1-11) analogs conformationally constrained by alpha-aminoisobutyric acid mediate full agonist responses via the juxtamembrane region of the PTH-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Autoactivation of type-1 parathyroid hormone receptors containing a tethered ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Residue 19 of the parathyroid hormone: structural consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Bovine Parathyroid Hormone: Minimum Chain Length of Synthetic Peptide Required for Biological Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Removal of partial agonism from parathyroid hormone (PTH)-related protein-(7-34)NH2 by substitution of PTH amino acids at positions 10 and 11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Studies of the N-terminal region of a parathyroid hormone-related peptide (1-36) analog: receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Dual signaling and ligand selectivity of the human PTH/PTHrP receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Nonlinear regression using spreadsheets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

A small molecule ligand of the glucagon-like peptide 1 receptor targets its amino-terminal hormone binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

A parathyroid hormone inhibitor in vivo: design and biological evaluation of a hormone analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408270200

21 January 2018

Identifiers

DOI

10.1074/JBC.M408270200

1 reference

21 September 2017

1 reference