Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: I. Investigation of the UDP-GlcNAc 2-epimerase functionality. (Q40501297)

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English	Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: I. Investigation of the UDP-GlcNAc 2-epimerase functionality.	scientific article

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4 January 2020

Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: I. Investigation of the UDP-GlcNAc 2-epimerase functionality (English)

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Astrid Blume

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Florian Stolz

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Richard R Schmidt

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Werner Reutter

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Stephan Hinderlich

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Thomas Peters

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21 October 2004

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Journal of Biological Chemistry

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4 January 2020

Sialic acid species as a determinant of the host range of influenza A viruses

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A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

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A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase

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Purification and characterization of N-acetylneuraminic acid-9-phosphate synthase from rat liver

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Tissue expression and amino acid sequence of murine UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase

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21 January 2018

Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis

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21 January 2018

The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy

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21 January 2018

Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme

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21 January 2018

UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation

1 reference

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21 January 2018

Sialylation is essential for early development in mice

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21 January 2018

Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

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Complete relaxation and conformational exchange matrix (CORCEMA) analysis of intermolecular saturation transfer effects in reversibly forming ligand-receptor complexes

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Refinement of the conformation of UDP-galactose bound to galactosyltransferase using the STD NMR intensity-restrained CORCEMA optimization

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The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases

1 reference

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21 January 2018

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, functionally expressed in and purified from Escherichia coli, yeast, and insect cells

1 reference

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21 January 2018

2',3'-Dialdehydo-UDP-N-acetylglucosamine inhibits UDP-N-acetylglucosamine 2-epimerase, the key enzyme of sialic acid biosynthesis

1 reference

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Sialic acid biosynthesis: stereochemistry and mechanism of the reaction catalyzed by the mammalian UDP-N-acetylglucosamine 2-epimerase

1 reference

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21 January 2018

Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: II. Investigation of the ManNAc kinase functionality

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Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site

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2-Acetamidoglucal, a new metabolite isolated from the urine of a patient with sialuria

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21 January 2018

The NeuC protein of Escherichia coli K1 is a UDP N-acetylglucosamine 2-epimerase

1 reference

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21 January 2018

Novel UDP-glycal derivatives as transition state analogue inhibitors of UDP-GlcNAc 2-epimerase

1 reference

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21 January 2018

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10.1074/JBC.M410238200

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15498764%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15498764%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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