Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy (Q40503541)

21 September 2017

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title

Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy (English)

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21 September 2017

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L W Jin

1

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PubMed ID

7711360

21 September 2017

T Saitoh

series ordinal

2

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21 September 2017

1 February 1995

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21 September 2017

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21 September 2017

6

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21 September 2017

2

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21 September 2017

136-149

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https://scigraph.springernature.com/pub.10.2165/00002512-199506020-00006

21 September 2017

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The protein kinase C family: heterogeneity and its implications

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Ultrastructural aspects of ageing rat hippocampus and effects of L-acetyl-carnitine treatment

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Neuron-specific protein F1/GAP-43 shows substrate specificity for the beta subtype of protein kinase C.

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Tacrine in Alzheimer's disease

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Differential involvement of protein kinase C isozymes in Alzheimer's disease

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Protein kinase C alteration is an early biochemical marker in Alzheimer's disease

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Down-regulation of protein kinase C is due to an increased rate of degradation

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The structure, expression, and properties of additional members of the protein kinase C family.

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Dopamine receptor sensitivity in brain and retina of rats during aging

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Regulation of phorbol ester binding and protein kinase C activity in aged rat brain.

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Modulation by palmitoyl-carnitine of calcium activated, phospholipid-dependent protein kinase activity and inhibition of melanoma cell growth.

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Patterns of aberrant sprouting in Alzheimer's disease

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Expression of the human B-cell surface protein CD20: alteration by phorbol 12-myristate 13-acetate

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Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat.

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Cyclosporin A inhibits proteolytic cleavage and degradation of membrane-bound protein kinase C in hepatocytes after stimulation by phorbol ester

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Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome

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Phosphoprotein phosphatase activities in Alzheimer disease brain

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12 December 2020

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12 December 2020

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12 December 2020

Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension

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12 December 2020

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12 December 2020

Tyrosine protein kinase activity in normal rat tissues: brain

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12 December 2020

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12 December 2020

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease

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12 December 2020

Therapeutic potential of protein kinase C inhibitors

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12 December 2020

Autoradiographic imaging of [3H]phorbol 12,13-dibutyrate binding to protein kinase C in Alzheimer's disease

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12 December 2020

Cyclic AMP-dependent protein kinase activity and synaptosomal protein phosphorylation in the brains of aged rats

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12 December 2020

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse

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12 December 2020

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12 December 2020

Receptor protein tyrosine kinases and phosphatases

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12 December 2020

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Subcellular distribution of adenosine 3',5'-monophosphate-dependent protein kinase in rat brain.

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Contrasting patterns of protein phosphorylation in human normal and Alzheimer brain: Focus on protein kinase C and protein F1GAP-43

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12 December 2020

Molecular insights into Alzheimer's disease

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12 December 2020

Phenothiazines reduce ischemic damage to the central nervous system

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12 December 2020

Protein kinase C--a question of specificity

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Impaired gene transcription and nuclear protein kinase C activation in the brain and liver of aged rats

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12 December 2020

Casein kinase II is associated with neurofibrillary tangles but is not an intrinsic component of paired helical filaments

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12 December 2020

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

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12 December 2020

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12 December 2020

Signalling by receptor tyrosine kinases

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12 December 2020

Nonreceptor tyrosine protein kinases.

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H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells

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12 December 2020

Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death

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12 December 2020

Protein kinases and phosphorylation in neurologic disorders and cell death

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12 December 2020

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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Advances in Alzheimer's disease

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12 December 2020

Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes

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12 December 2020

Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease

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12 December 2020

Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release

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12 December 2020

The survival of rat cerebral cortical neurons in the presence of trophic APP peptides.

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12 December 2020

Tacrine as a treatment for Alzheimer's dementia: editor's note. An interim report from the FDA. A response from Summers et al

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12 December 2020

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

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12 December 2020

Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain.

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12 December 2020

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

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12 December 2020

Protein tyrosine kinase activity and its endogenous substrates in rat brain: a subcellular and regional survey

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12 December 2020

Tyrosine phosphorylation in early embryonic growth cones.

1 reference

12 December 2020

Localization of a defect in hypothalamic dopaminergic neurons of the aged brain that results in impaired PKA-dependent activation of tyrosine hydroxylase

1 reference

12 December 2020

Inhibition of gap junctional blockage by palmitoyl carnitine and TMB-8 in a rat liver epithelial cell line

1 reference

12 December 2020

CARNITINE AND ITS ROLE IN FATTY ACID METABOLISM

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12 December 2020

Epidermal growth factor receptor expression in demented elderly: localization to vascular endothelial cells of brain, pituitary and skin.

1 reference

12 December 2020

The trk proto-oncogene encodes a receptor for nerve growth factor

1 reference

12 December 2020

The involvement of protein kinase C in activation-induced cell death in T-cell hybridoma

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12 December 2020

Tissue distribution and quantitation of the mRNAs for three rat tachykinin receptors

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12 December 2020

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

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12 December 2020

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

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12 December 2020

Mutagenesis of the regulatory domain of rat protein kinase C-eta. A molecular basis for restricted histone kinase activity.

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12 December 2020

Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis

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12 December 2020

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

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12 December 2020

Cerebral hypoxia: some new approaches and unanswered questions

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12 December 2020

Inhibition of epidermal growth factor binding in rat pancreatic acini by palmitoyl carnitine: evidence for Ca2+ and protein kinase C independent regulation.

1 reference

12 December 2020

Selective alterations of high affinity [3H]forskolin binding sites in Alzheimer's disease: a quantitative autoradiographic study.

1 reference

12 December 2020

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

1 reference

12 December 2020

Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease

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12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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12 December 2020

The role of protein kinase C in transmembrane signalling

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12 December 2020

BDNF and trkB mRNA expression in the hippocampal formation of aging rats

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12 December 2020

Reduction of low-molecular-weight acid phosphatase activity in Alzheimer brains

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12 December 2020

10.2165/00002512-199506020-00006

Identifiers

DOI

1 reference

PubMed ID

7711360

Dimensions Publication ID

21 September 2017

0 references

1 reference

PubMed ID

7711360